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HLA system

HLA system

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HLA system (human leucocyte antigen system) A series of four gene loci (A, B, C, and D) in humans that code for a group of glycoproteins, present on the surface of plasma membranes, that act as antigens and are important in determining the acceptance or rejection by the body of a tissue or organ transplant (see graft). These antigens are one group of the so-called histocompatibility proteins (see histocompatibility). Two individuals with identical HLA types are said to be histocompatible. Successful transplantation requires a minimum number of HLA differences between the donor's and recipient's tissues. See also major histocompatibility complex.

A Dictionary of Biology

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