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Chemonucleolysis is a medical procedure that involves the dissolving of the gelatinous cushioning material in an intervertebral disk by the injection of an enzyme such as chymopapain.


Between each vertebra lies a disk of cushioning material that keeps the spinal bones from rubbing together and absorbs some of the shock to the spine from body movements. In the center of the disk is soft, gelatinous material called the nucleus pulposus (NP). The NP is surrounded by a tough fibrous coating. Sometimes when the back is injured, this coating can weaken and bulge or tear to allow the NP to ooze out. When this happens, it is called a herniated nucleus pulposus (HNP), orin common languagea herniated disk.

When the disk bulges or herniates, it can put pressure on nerves which originate in the spinal column, and go to other parts of the body. This causes lower back pain, and/or pain to the hips, legs, arms, shoulders, and neck, depending on the location of the herniated disk. Chemonucleolysis uses chymopapain, an enzyme derived from papyrus, to dissolve the disk material that has been displaced because of injury. Herniated disks are the cause of only a small proportion of cases of lower back pain, and chemonucleolysis is appropriate for only some cases of HNP.

Chemonucleolysis is a conservative alternative to disk surgery. There are three types of disk injuries. A protruded disk is one that is intact but bulging. In an extruded disk, the fibrous wrapper has torn and the NP has oozed out, but is still connected to the disk. In a sequestered disk, a fragment of the NP has broken loose from the disk and is free in the spinal canal. Chemonucleolysis is effective on protruded and extruded disks, but not on sequestered disk injuries. In the United States, chymopapain chemonucleolysis is approved only for use in the lumbar (lower) spine. In other countries, it has also been used successfully to treat cervical (upper spine) hernias.

Other indications that a patient is a good candidate for chemonucleolysis instead of surgery include:

  • the patient is 18-50 years of age
  • leg pain is worse than lower back pain
  • other conservative treatments have failed
  • The spot where the herniated disk presses on the nerve has been pinpointed by myelography, computed tomography scan (CT scan), or magnetic resonance imaging (MRI)
  • the patient wishes to avoid surgery


There are some situations in which chemonucleolysis should not be performed. Chymopapain is derived from the papaya. About 0.3% of patients are allergic to chymopapain and go into life-threatening shock when exposed to the enzyme. Chemonucleolysis should not be performed on patients allergic to chymopapain or papaya. It also should not be done:

  • when the patient is pregnant
  • if the disk is sequestered
  • if the patient has had several failed back operations
  • if a spinal cord tumor is present
  • if the patient has a neurological disease such as multiple sclerosis

Other conditions may affect the appropriateness of chemonucleolysis, including hypertension, obesity, diabetes, and a family history of stroke.


A small gauge needle is placed in the center of the affected disk. Chymopapain is introduced into the disk. The patient needs to remain still.


Patients will need tests such as a myelogram or CT scan to pinpoint the herniated disk. Some doctors medicate the patient 24 hours prior to the operation in order to decrease the chances of post-operative lower back stiffness.


Patients may feel lower back stiffness, which goes away in few weeks. Heavy lifting and sports activities should be avoided for at least three months.


The greatest risk is that the patient may be allergic to chymopapain. The death rate for chemonucleolysis is only 0.02%. Complications overall are five to 10 times less than with conventional surgery, and the failure rate is roughly comparable to the failure rate in conventional disk surgery.

Normal results

Many patients feel immediate relief from pain, but, in about 30% of patients, maximal relief takes six weeks. The long term (seven to 20 years) success rate averages about 75%, which is comparable to the success rate for conventional surgery.



Alexander, Herbert. "Chemonucleolysis for Lumbar Disc Herniation: How Does it Stack up to Other Minimally Invasive Approaches?" Journal of Musculoskelatal Medicine 12, no. 2 (1995): 13-24.


Chymopapain An enzyme from the milky white fluid of the papaya, used for medical purposes in chemonucleolysis.

Myelography An x-ray test that evaluates the subarachnoid space of the spine.

Nucleus pulposus (NP) an elastic, pulpy mass in the center of each vertebral disk.