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nuke / n(y)oōk/ inf. • n. a nuclear weapon. ∎  a nuclear power station. ∎  a nuclear-powered vessel. • v. [tr.] attack or destroy with nuclear weapons. ∎  destroy; get rid of: I fertilized the lawn and nuked the weeds. ∎  cook or heat up (food) in a microwave oven: I nuked a quick burger.