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in·fa·mous / ˈinfəməs/ • adj. well known for some bad quality or deed: an infamous war criminal. ∎  wicked; abominable: the medical council disqualified him for infamous misconduct. ∎  hist. Law (of a person) deprived of all or some citizens' rights as a consequence of conviction for a serious crime.DERIVATIVES: in·fa·mous·ly·fa·my / -mē/ n. (pl. -mies) .