spironolactone (spy-rŏ-noh-lak-tohn) n. a synthetic corticosteroid that inhibits the activity of the hormone aldosterone and is administered by mouth as a potassium-sparing diuretic to treat fluid retention (oedema) in cirrhosis, ascites, and severe heart failure. It is also used in treating aldosteronism. Trade name: Aldactone.
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