readthrough
readthrough The continuation of transcription of DNA beyond a normal stop signal, or terminator sequence, due to failure of RNA polymerase to recognize the signal. Readthrough can also occur in translation, when a mutation has converted a normal stop codon into one encoding an amino acid. This results in extension of the polypeptide chain until the next stop codon is reached, producing a so-called readthrough protein.
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Nonsense Mutation , nonsense mutation A mutation that alters a gene so that a nonsense codon is inserted. Such a codon is one for which no normal t-RNA molecule exists:… diapason , diapason •Masson •flaxen, Jackson, klaxon, Sachsen, Saxon, waxen •Samson •Branson, Jansen, Manson, Nansen •arson, Carson, fasten, parson, sarsen •Bre… Glottal Stop , GLOTTAL STOP. In PHONETICS, a stop sound made by bringing the VOCAL CORDS tightly together, blocking off the airstream and sealing the GLOTTIS, then… endopeptidase , endopeptidase A protein-digesting enzyme that cleaves a polypeptide chain at specific sites between amino acids. For example, chymotrypsin cleaves th… doorstop , doorstop •atop, bop, chop, clop, cop, crop, dop, drop, Dunlop, estop, flop, fop, glop, hop, intercrop, knop, kop, lop, mop, op, plop, pop, prop, scre… Protein Synthesis , There is no task more important to the function of living cells than the synthesis of proteins. Because proteins carry out so many different tasks, t…
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readthrough