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Lysergic Acid Diethylamide (LSD)

Lysergic Acid Diethylamide (LSD)

Definition

Lysergic acid diethylamide (LSD), also known as "acid," belongs to a class of drugs known as hallucinogens, which distort perceptions of reality. LSD is the most potent mood- and perception-altering drug known: doses as small as 30 micrograms can produce effects lasting six to 12 hours.

Purpose

In the United States, LSD has no accepted medical use and its manufacture is illegal.

Description

LSD is produced synthetically from a fungus that grows on rye grass. This odorless, colorless, and slightly bitter-tasting chemical is generally ingested orally and absorbed from the gastrointestinal system. Manufacturers commonly distribute LSD in small squares of absorbent paper soaked with the drug, which users chew and swallow. Use of LSD and other hallucinogens by secondary school students has decreased since 1998, but has increased among older teens and young adults attending dance clubs and all-night raves, according to the National Institute on Drug Abuse.

LSD alters perceptions by disrupting the action of the neurotransmitter serotonin, although precisely how it does this is unclear. Studies suggest LSD acts on certain groups of serotonin receptors, and that its effects are most prominent in two brain regions: the cerebral cortex and the locus ceruleus. The cerebral cortex is involved in mood and perception, and the locus ceruleus receives sensory signals from all areas of the body. Natural hallucinogens resembling LSD, such as mescaline and psilocybin, have been used in social and religious rituals for thousands of years.

After its discovery in 1938, LSD was used experimentally to treat neuroses, narcotic addiction, autism, alcoholism, and terminally ill cancer patients, and to study the mechanisms of psychotic diseases like schizophrenia. Nearly 30 years after its discovery, manufacture, possession, sale, and use of LSD was restricted in the United States under the Drug Abuse Control Amendment of 1965.

LSD's effects generally begin within an hour of taking the drug and last for up to 12 hours. The drug is absorbed from the gastrointestinal tract, and circulated throughout the body and to the brain. It is metabolized in the liver and excreted in the urine about 24 hours after ingestion. Physical effects of LSD may include loss of appetite, sleeplessness, pupil dilation, dry mouth, salivation, palpitations, perspiration, nausea, dizziness, blurred vision, and anxiety, as well as increased body temperature, heartbeat, blood pressure, and blood sugar.

The major effects of LSD are emotional and sensory. Emotions may shift instantaneously from euphoria to confusion and despair, and users may feel as if they are experiencing several emotions simultaneously. Colors, smells, and sounds may be highly intensified, and time may appear to move very slowly. Sensory perceptions may blend in a phenomenon known as synesthesia, in which a person sees sounds, or smells colors, for example. Users may have out-of-body sensations, or may perceive their body has changed shape or merged with another person or object.

Precautions

Unlike cocaine, amphetamines, heroin, alcohol, and nicotine, LSD is not considered addictive, but it is considered dangerous; users are at risk for several short- and long-term side effects. LSD's effects are unpredictable and may vary with the amount ingested and the user's personality, mood, expectations, and surroundings. Users may experience enjoyable sensations on some "trips," and terrifying feelings of anxiety and despair on others. Most LSD-related deaths stem not from the LSD's physical effects on the body, but from the panicked reactions ensuing from intense LSD-triggered illusions.

Side Effects

Two long-term effects are associated with LSD use: psychosis, and hallucinogen persisting perception disorder (HPPD), also known as "flashbacks." The exact causes of these effects, including the mechanism by which LSD may cause them, is unknown. Chronic hallucinogen users or individuals with underlying personality problems are most vulnerable to these effects, but individuals with no history of psychological disorders have also experienced them. LSD-induced psychosis may include dramatic mood swings, loss of cognitive and communication skills, and hallucinations. Flashbacks generally involve seeing bright flashes, or halos or trails attached to moving objects after the LSD "trip" has ended. Flashbacks can last a few seconds or even several hours.

KEY TERMS

Acid Common street name for LSD.

Cerebral cortex Brain region responsible for reasoning, mood, and perception.

Hallucinogen A drug that distorts sensory perceptions and disturbs emotion, judgment, and memory.

Hallucinogen persisting perception disorder (HPPD) The recurrence of LSD effects after the drug experience has ended.

Locus ceruleus Brain region that processes sensory signals from all areas of the body.

Neurotransmitter Chemical compound in the brain that transmits signals from one nerve cell to another.

Serotonin A neurotransmitter that modulates the actions of other neurotransmitters in the brain.

According to the Drug Abuse Warning Network (DAWN), the number of LSD-related hospital emergencies is low compared to those related to cocaine, heroin, marijuana, methamphetamine, and other illicit drugs. One reason for this trend may be that LSD currently sold on the black market is less potent than in the past. LSD dose strengths tend to range from 20 to 80 micrograms today, compared to 100 to 200 micrograms reported during the 1960s and early 1970s.

Interactions

LSD flashbacks can be spurred by use of drugs such as marijuana. Preliminary evidence suggests serotonin reuptake inhibitors like Prozac and Zoloft may also exacerbate the LSD flashback syndrome.

Resources

PERIODICALS

Aghajanian, G. K. and G. J. Marek. "Serotonin and Hallucinogens." Neuropsychopharmacology 1999: 16S-23S

ORGANIZATIONS

National Clearinghouse for Alcohol and Drug Information. 11426 Rockville Pike, Suite 200, Rockville, MD. 20852. (800) 729-6686. http:\\www.health.org.

National Institute on Drug Abuse. P.O. Box 30652, Bethesda, MD. 20824-0652. (888) 644-6432. http:\\www.drugabuse.gov.

U.S. Department of Justice, Drug Enforcement Administration. 2401 Jefferson Davis Highway, Alexandria, VA 22301. (888) 644-6432. http:\\www.usdoj.gov/dea.

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LSD

LSD


LSD is the abbreviation for lysergic acid diethylamide, a synthetic hallucinogenic drug discovered by Albert Hofmann in 1938. By disrupting the action of serotonin in the brain, LSD produces markedly abnormal behavior, including psychotic episodes that can last anywhere from hours to several days. The drug is usually administered through the tongue, although it can be absorbed through any of the mucous membranes.

Medical experimentation with LSD began in the 1950s, soon after the Swiss pharmaceutical firm Sandoz Laboratories began legally manufacturing the drug. Early investigators included Oscar Janiger, a Los Angeles psychiatrist who administered LSD to approximately 1,000 volunteers between 1954 and 1962, and Timothy Leary, a Harvard psychology professor, who experimented with LSD during the early 1960s. Leary administered the drug to Harvard students, helping to spark an interest in it on college campuses around the nation. Like Janiger, Leary also gave the drug to a number of celebrities. Harvard fired Leary in 1963, but he continued his experiments and advocacy of what had come to be called psychedelic drugs. While the United States government had initially sponsored covert investigations into the utility of LSD for the military and other agencies, in response to mounting public concern and a Senate inquiry, the government outlawed LSD in 1966.

LSD moved rapidly from medicinal to recreational use. Interest in the drug was greatly stimulated by accounts of celebrities, including the actor Cary Grant, and artists who reported remarkable psychological insights and transformations after using LSD. The drug was touted as an aphrodisiac and as a chemical adjunct to the "hippie" movement. It was widely distributed through illegal channels during the 1960s to those eager to follow Leary's siren call to "turn on, tune in, drop out." When LSD was outlawed by most countries and abandoned by legal pharmaceutical manufacturers, any early promise it had as a therapeutic drug was lost in a wave of bad experiences associated with its illegal use and unregulated production.

BIBLIOGRAPHY

Lee, Martin, and Bruce Shlain. Acid Dreams: The Complete Social History of LSD: The CIA, the Sixties, and Beyond. New York: Grove Press, 1985.

Montagne, Michael. "LSD at 50: Albert Hofmann and His Discovery." Pharmacy in History 35 (1993): 7073.

Stevens, Jay. Storming Heaven: LSD and the American Dream. New York: Grove/Atlantic, 1998.

Ulrich, Robert F., and Bernard M. Patten. "The Rise, Decline, and Fall of LSD." Perspectives in Biology and Medicine 34 (19901991): 561578.

Loren Butler Feffer

See also Counterculture ; Substance Abuse .

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LSD

LSD or lysergic acid diethylamide (lī´sûr´jĬk, dī´ĕth´ələmĬd, dī´ĕthəlăm´Ĭd), alkaloid synthesized from lysergic acid, which is found in the fungus ergot (Claviceps purpurea). It is a hallucinogenic drug that intensifies sense perceptions and produces hallucinations, mood changes, and changes in the sense of time. It also can cause restlessness, acute anxiety, and, occasionally, depression. Although lysergic acid itself is without hallucinogenic effects, lysergic acid diethylamide, one of the most powerful drugs known, is weight for weight 5,000 times as potent as the hallucinogenic drug mescaline and 200 times as potent as psilocybin. LSD is usually taken orally from little squares of blotter paper, gelatin "windowpanes," or tiny tablets called microdots. The period of its effects, or "trip," is usually 8 to 12 hours. Unexpected reappearances of the hallucinations, called "flashbacks," can occur months after taking the drug. The drug does not appear to cause psychological or physical dependence. The danger of LSD is that its effects are unpredictable, even in experienced users.

History

LSD was developed in 1938 by Arthur Stoll and Albert Hofmann, Swiss chemists hoping to create a headache cure. In 1943 Hofmann accidentally ingested some of the drug and discovered its hallucinogenic effect. In the 1960s and 70s it was used by millions of young people in America; its popularity waned as its reputation for bad trips and resulting accidents and suicides became known. In 1967, the federal government classified it as a Schedule I drug, i.e., having a high abuse potential and no accepted medical use, along with heroin and marijuana. In the early 1990s it again became popular, presumably because of its low cost. It is produced in clandestine laboratories.

Bibliography

See publications of the Drugs & Crime Data Center and Clearinghouse, the Bureau of Justice Statistics Clearinghouse, and the National Clearinghouse for Alcohol and Drug Information.

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lysergic acid diethylamide

lysergic acid diethylamide (LSD) (ly-ser-jik ass-id dy-eth-il-ay-myd) n. a hallucinogenic drug, formerly used to aid treatment of psychological disorders. Alterations in sight, hearing, and other senses occur, psychotic effects, depression, and confusion are common, and tolerance to the drug develops rapidly. Because of these toxic effects, LSD is no longer used clinically.

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LSD

LSD (lysergic acid diethylamide) Hallucinogenic drug, causing changes in mental state, sensory confusion and behavioural changes, resulting from the drug blocking the action of serotonin in the brain. First synthesized in the 1940s, LSD was made illegal in the UK and USA in the mid-1960s.

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lysergic acid diethylamide

lysergic acid diethylamide (LSD) A chemical derivative of lysergic acid that has potent hallucinogenic properties (see hallucinogen). It occurs in the cereal fungus ergot and was first synthesized in 1943. LSD acts as an antagonist at serotonin receptors.

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LSD

LSD • abbr. lysergic acid diethylamide, a synthetic crystalline compound, C20H26N2O, that is a potent hallucinogenic drug.

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LSD

LSD, LSB Abbrevs. for least significant digit, least significant bit. See least significant character.

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lysergic acid diethylamide

lysergic acid diethylamide: see LSD.

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LSD

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LSD

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LSD

LSD League of Safe Drivers
• Computing least significant digit
• Lightermen, Stevedores, and Dockers
• lysergic acid diethylamide (hallucinogenic drug)

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LSd

LSd (or £Sd) symbol for Sudanese pound (monetary unit)

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LSD

LSD

LSD is an acronym for lysergic acid diethylamide, also commonly known as acid. It is a powerful psychedelic drug that induces a temporary psychotic state that may include hallucinations and "deep insight" into the nature of things, say its adherents who made it into one of the counterculture's drugs of choice, especially during the 1960s. Developed by the CIA a decade earlier as a counter-espionage mind-controlling agent, LSD was initially intended for psychological torture during the Cold War. Psychiatrists later studied the drug as a means of observing their patients' uninhibited anxieties, and it was also used, with some success, to treat schizophrenia and autism in children, and chronic alcoholism and heroin addiction. In the 1950s, hundreds of subjects, including Hollywood and media celebrities and prominent artists, participated in experimental trips under the direction of Dr. Oscar Janiger, a Los Angeles-area psychiatrist, and other local therapists.

Not until LSD was widely ingested recreationally, though, at the urging of Dr. Timothy Leary and others, did it attain near-sacramental status among the avatars of mind-expansion after about 1965. "Drop-ping" acid evolved into a tribal act of civil disobedience, and some of the best minds of the twentieth century dabbled with LSD while seeking spiritual enlightenment. Many who advocate the unrestricted use of LSD charge that Sandoz cut off access to the drug for research purposes under pressure from prohibitionists who feared its impact on cultural transformation when it became a drug of choice in the youth community in the late 1960s. Some advocates believe reports of "bad trips" (psychotic episodes, going blind from staring at the sun, suicides by leaping from tall buildings) are exaggerated urban myths; they claim moderate doses of the drug do not produce such extreme effects, and that the draconian prohibition of the drug prevented researchers from devising safer regimens for ingesting it. In the 1980s and 1990s, "disco doses" of contraband LSD were often distributed via "blotter paper," sheets of cartoon-like decals that were chewed and ingested.

Dr. Albert Hoffman first synthesized LSD in 1938 at Sandoz Laboratories in Switzerland while researching ergot, the hallucinogenic rye fungus that is the natural source of lysergic acid. There he stumbled onto a powerful serotonin inhibitor he called LSD-25 (the twenty-fifth in a series of ergot derivatives) which produced intensely vivid hallucinations and altered states of perception. In 1943, he unwittingly absorbed the drug through his fingers, inducing a mild hallucinogenic state that he tried to duplicate several days later by deliberately dosing himself with 250 micrograms. Hoffman published his findings, but Sandoz soon lost interest in his experiments.

In 1942, however, the OSS (Office of Strategic Services, predecessor of the Central Intelligence Agency) assembled a group of military scientists to examine the possibilities of a "truth drug" for deployment on political prisoners, and they tried a host of increasingly powerful pharmaceuticals to this end throughout the 1940s, often with dubious results. After World War II, the CIA consulted academics and psychiatrists as well as police crime labs to help expand its chemical-knowledge base. By the 1950s, the CIA had developed an "anything goes" attitude toward this objective, which eventually led to exploration of the shelved projects at Sandoz.

The CIA first used LSD on human subjects in 1951 and intensified its research, spurred by the growing fear of communist espionage. Researchers found that the effects of LSD could vary wildly according to personal and social expectations (the set) and the physical surroundings (the setting) during the "trip," so agents were directed to "dose" themselves and each other to become familiar with the drug's potential. In 1953 the CIA launched Operation MK-ULTRA, which authorized "surprise tests" on civilians, and by 1955 had opened a safe house in the Haight-Ashbury district of San Francisco that lured unwitting subjects for a taste of the new drug in "real life" situations. Acid's unpredictable nature eventually led to more specialized hallucinogens, and the CIA discontinued the safe-house project in 1964, but by then LSD was already turning heads in the academic community. From the mid-1950s, Dr. Oscar Janiger carried out his experiments without accepting any funding from the CIA or the military. Instead, he charged subjects $20 per visit and used drugs supplied by Sandoz. Among the 900-odd visitors to his LSD "salon" were his cousin, the Beat poet Allen Ginsberg, writer Anaïs Nin, Zen philosopher Alan Watts, novelist Christopher Isherwood, actors James Coburn, Dennis Hopper, and Jack Nicholson, and a group of Unitarian ministers who were disappointed that they had not experience hoped-for spiritual transcendence. Besides Dr. Janiger, other southern California psychiatrists who dispensed experimental doses to their clients included Dr. Arthur Chandler, who gave the drug to actor Cary Grant as a treatment for alcoholism; and Dr. Sidney Cohen, who "turned on" Henry Luce (of Time magazine) and Clare Boothe Luce, his wife. Luce perhaps achieved a better record of transcendence than did the Unitarian ministers when he reported an encounter with God on a golf course; his wife thought that LSD should be given only to the elite, saying, "We wouldn't want everyone doing too much of a good thing." In a 1998 interview, Dr. Janiger offered the drug-induced Eleusinian Mysteries in ancient Greece as a possible model for the creative use of LSD in contemporary culture: "The discussions I had with [Aldous] Huxley and [Alan] Watts and the others in those early years centered on the way our culture might institutionalize LSD … and it would be very much like the Greek model."

Psychotropic treatment had caught the eye of Aldous Huxley whose book The Doors of Perception exposed the educated public to the possibilities of an intellectual, "psychedelic" experience. By 1957 experiments with LSD and the creative mind were being conducted by a clinical psychologist at Harvard named Timothy Leary who experienced a shamanic state and beatific visions while on acid. He and his colleagues claimed mass "tripping" could foster a new age of philosophical peace and freedom, and Leary spoke widely about the drug's positive applications, though other researchers dubbed these theories "instant enlightenment."

When the CIA abandoned serious LSD research, the scientific community lost its government supply of the drug, and Leary and others continued their research underground, supplying themselves with acid from a growing black market. There were many self-styled experts on LSD in the mid 1960s, many of whom had first been dosed in military-sponsored tests at Stanford, Harvard, and other universities, and most subscribed to the ideal of a unifying group trip. These communal experiments were tried on the east and west coasts of the United States, and it was Ken Kesey who mobilized this new wave of positive if absurdist religiosity based largely on the acid trip.

In 1959, Kesey, a recent Woodrow Wilson fellow at Stanford University, had been a $75-a-day guinea pig in LSD experiments at the Veterans' Administation Hospital in Menlo Park, where he remained employed as a mental-ward attendant after his part in the experiments were completed. His experiences there formed the basis for his celebrated 1962 novel One Flew Over the Cuckoo's Nest. Two years after its publication, Kesey and a group of friends who dubbed themselves the Merry Pranksters set off on a cross-country trip (destination: the New York World's Fair) in a garishly painted old schoolbus, creating "happenings" along the way and extolling the virtues of psychedelia and hallucinogens as a bridge to harmony and understanding. The trip was itself memorialized in Tom Wolfe's 1968 book, The Electric Kool-Aid Acid Test. Kesey tried to unite the mystique of drug lifestyle with politically-conscious activism, and subsequent "acid tests" encouraged participants to confront the cosmic umbilical cord of the ego while high on LSD. Simultaneously, writers and musicians were "turning on" and psychedelicizing their work-most notably Allen Ginsberg, Hunter S. Thompson, Bob Dylan, The Beatles, and The Grateful Dead-further enhancing LSD's role as a folk remedy of sorts for the hippie nation, and a recreational enabler for both deep introspection and outrageous social protest. It has long been supposed by many Beatles fans that the band's 1967 song "Lucy in the Sky with Diamonds" (an acronym for LSD) was inspired by an acid trip, though Paul McCartney told Joan Goodman in a 1984 Playboy interview that the song was merely about "a drawing that John's son [Julian] brought home from school" and about one of his classmates named Lucy. Also in that year, Jack Nicholson, one of Dr. Janiger's subjects, included his experiences in his script for a 1967 low-budget film The Trip, that starred another subject, Dennis Hopper, and Peter Fonda.

The Haight-Ashbury district of San Francisco—site of the government's earlier safe-house projects—became the hub of a psychedelic revolution. Here, black market acid was first sold on a mass scale, with acid manufacturers convinced they were performing an important public service. But just as the community began to throb with acid tests, free rock concerts, street theater, and full-blown psychedelia, LSD was made illegal in 1966 and Sandoz ceased its medical research distribution due to the bad press acid was receiving. Many blamed Leary's early outspokenness for the crackdown, but changes in attitude toward LSD research had already demonized the drug. Doctors now began speaking out publicly against the use of LSD, but this only served to inform more potential users (mostly young, well-educated, white middle-class users) about the drug. By the 1967 Summer of Love, it seemed as if all of America was "turning on" or trekking west to San Francisco where the action was, though the progenitors of acid culture were already burning out. The Haight, once an idyllic nexus, became a psychedelic tourist trap, and soon a pharmacopoeia of designer drugs (of which LSD was one of the weakest) emerged on the scene to bolster the waning euphoria.

In the wake of many highly-publicized, violent confrontations with authority, acid culture subsided by the early 1970s into a cabal of psychedelic drug devotees, convinced that they were being denied access to transcendence by fearful guardians of straight society. Much of LSD's early cultural history has been told in Jay Stevens's 1987 Grove Press book, Storming Heaven: LSD & the American Dream. By the 1990s, however, a nonprofit advocacy group called the Multidisciplinary Association for Psychedelic Studies (MAPS) was lobbying the Food and Drug Administration to approve medical studies of LSD as well as marijuana and other drugs like the popular Ecstasy. The group, which includes a number of prominent research scientists, was founded by Rick Doblin in the hopes of continuing Dr. Janiger's important but aborted research. As Dr. Janiger told an interviewer in 1998, "LSD didn't pan out as an acceptable therapeutic drug for one reason: Researchers didn't realize the explosive nature of the drug … You can't manipulate it as skillfully as you would like. It's like atomic energy—it's relatively easy to make a bomb, but much harder to safely drive an engine and make light. And with LSD, we didn't have the chance to experiment and fully establish how to make it do positive, useful things."

At the end of the twentieth century, "hits" of LSD were most frequently available on colorful blotter-paper decals, permitting easy ingestion of "disco doses" far below those responsible for the well-publicized "bad trips" of earlier times. Artists like Mark McCloud have compiled a huge archive of these blotter-paper designs, which he considers an example of late-twentieth-century folk art. LSD is no longer tantamount to social defiance, but has become a metaphor for the search for enlightenment via ritualistic drug use in an urban, industrialized society, and also for the multifarious waves of cultural experimentation it inspired in the America of the 1960s. As a gateway to global transcendence at the millennium, LSD still inspires many testimonials on the World Wide Web's alt.culture sites, and researchers have begun to take a new and more favorable look at the once-demonized drug.

—Tony Brewer

Further Reading:

Jaffe, Jerome H., M.D. Encyclopedia of Drugs and Alcohol, Volume 2. New York, Macmillan, 1995.

Leary, Timothy, Ralph Metzner, and Richard Alpert. The Psychedelic Experience: A Manual Based on the Tibetan Book of the Dead. New York, University Books, 1964.

Lee, Martin A., and Bruce Shlain. Acid Dreams: The CIA, LSD, and the Sixties Rebellion, New York, Grove Press, 1985.

"LSD." http://www.altculture.com. June 1999.

Stevens, Jay. Storming Heaven: LSD & the American Dream. New York, Grove Press, 1987.

Whalen, John. "The Hollywood Experiment." L.A. Weekly. July 3,1998; reprinted in Utne Reader. November-December, 1998, 81-5, 114-18.

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