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res·ig·na·tion / ˌrezigˈnāshən/ • n. 1. an act of retiring or giving up a position: he announced his resignation. ∎  a document conveying someone's intention of retiring: I'm thinking of handing in my resignation. ∎ Chess an act of ending a game by conceding defeat without being checkmated.2. the acceptance of something undesirable but inevitable: a shrug of resignation.