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ir·ri·ta·ble / ˈiritəbəl/ • adj. having or showing a tendency to be easily annoyed or made angry: she was tired and irritable. ∎ Med. (of a bodily part or organ) abnormally sensitive. ∎  Med. (of a condition) caused by such sensitivity. ∎  Biol. (of a living organism) having the property of responding actively to physical stimuli.DERIVATIVES: ir·ri·ta·bil·i·ty / ˌiritəˈbilitē/·ri·ta·bly / -blē/ adv.