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des·ig·na·tion / ˌdezigˈnāshən/ • n. the choosing and naming of someone to be the holder of an official position: a leader's designation of his own successor. ∎  the action of choosing a place for a special purpose or giving it a special status: the designation of parts of Santa Ana as an enterprise zone. ∎  a name, description, or title, typically one that is officially bestowed: a group of tribes banded together under the designation “Sheepeaters.”