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neovascularization (nee-oh-vas-kew-ler-I-zay-shŏn) n. the abnormal formation of new and fragile blood vessels, usually in response to ischaemia. choroidal n. the growth of abnormal vessels, derived from the choroid, to form a choroidal neovascular membrane in the space below the retinal pigment epithelium (see retina). This occurs, for example, in macular degeneration.