gonadorelin analogue (GnRH analogue, LHRH analogue) (gon-ă-doh-rel-in) n. a synthetic analogue of gonadotrophin-releasing hormone, which stimulates the production of pituitary gonadotrophins (luteinizing hormone and follicle-stimulating hormone). Gonadorelin analogues include goserelin (Zoladex), leuprorelin (Prostap), and triptorelin (Decapeptyl, Gonapeptyl Depot). Administered by subcutaneous or intramuscular injection or by nasal spray, they are used in the treatment of endometriosis, fibroids, some types of infertility, and advanced prostate cancer. See also buserelin.
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