extrapyramidal effects (extrapyramidal side-effects, EPS) (eks-tră-pi-ram-i-d'l) pl. n. symptoms caused by a reduction of dopamine activity in the extrapyramidal system due to the adverse effects of dopamine receptor antagonists, notably phenothiazine antipsychotic drugs. These effects include parkinsonism, akathisia, and dyskinesia.
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