base analogue
base analogue A purine or pyrimidine base (see BASE PAIR) that differs slightly in structure from the normal base, but that because of its similarity to that base may act as a mutagen when incorporated into DNA. Once in place, these bases, which have pairing properties unlike those of the bases they replace, can produce mutations by causing insertions of incorrect nucleotides opposite them during replication. Though the original base analogue exists only in a single strand, it can cause a nucleotide-pair substitution that is replicated in all DNA copies descended from that original strand. An example is 5-bromo-uracil (5BU), an analogue of thymine that has bromine at the C-5 position in place of the CH3 group found in thymine.
base analogue
base analogue A purine or pyrimidine base that differs slightly in structure from the normal base, but that because of its similarity to that base may act as a mutagen when incorporated into DNA. Once in place, these bases, which have pairing properties unlike those of the bases they replace, can produce mutations by causing insertions of incorrect nucleotides opposite them during replication. Though the original base analogue exists only in a single strand, it can cause a nucleotide-pair substitution that is replicated in all DNA copies descended from that original strand. An example is 5-bromo-uracil (5BU), an analogue of thymine that has bromine at the C-5 position in place of the CH3 group found in thymine.
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Base Pairing , James Watson and Francis Crick proposed the molecular structure of deoxyribonucleic acid (DNA ) in 1952. Gathering a number of experimental findings… Anticodon , anticodon A triplet sequence of nucleotides in transfer-RNA that during protein synthesis (see RIBOSOME) binds by base pairing to a complementary seq… Dna Hybridization , Evolution deals with heritable changes in populations over time. Because DNA is the molecule of heredity, evolutionary changes will be reflected in c… Wobble Hypothesis , wobble hypothesis A theory proposed to explain the partial degeneracy of the genetic code in that some t-RNA molecules can recognize more than one co… Base , base1 / bās/ • n. 1. the lowest part or edge of something, esp. the part on which it rests or is supported: she sat down at the base of a tree. ∎ Arc… Nucleotide , Nucleotides are the building blocks of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Individual nucleotide monomers (single units) are link…
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