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Calpurnia (kălpûr´nēə), d. after 44 BC, Roman matron. The daughter of Lucius Calpurnicus Piso Caesoninus (see under Piso, family), she was married to Julius Caesar in 59 BC She was loyal to him despite his many infidelities and his neglect. The picture of her in Shakespeare's Julius Caesar is drawn mainly from Plutarch.