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Sedation, conscious

Sedation, conscious

Definition
Purpose
Description
Monitoring
Risks and risk management

Definition

Conscious sedation, produced by the administration of certain medications, is an altered level of consciousness that still allows a patient to respond to physical stimulation and verbal commands, and to maintain an unassisted airway.

Purpose

The purpose of conscious sedation is to produce a state of relaxation and/or pain relief by using benzodiazepine-type and narcotic medications to facilitate a procedure such as a biopsy, radiologic imaging study, endoscopic procedure, radiation therapy, or bone marrow aspiration.

Description

Sedation is used inside or outside the operating room. Outside the operating suite, medical specialists use sedation to calm and relax their patients.

If the patient is to undergo a minor surgical procedure, screening and assessment of medical conditions that may interfere with conscious sedation must be explored. These potential risk factors include advanced age, history of adverse reactions to the proposed medications, and a past medical history of severe cardiopulmonary (heart/lung) disease. Other than those risk factors, contraindications for conscious sedation include; recent ingestion of large food or fluid volumes or a physical class IV or greater.

Once it has been established that the patient would be a good candidate for conscious sedation, just prior to the surgery or procedure, the patient will receive the sedating drug intravenously. A clip-like apparatus will be placed on the patient’s finger to monitor oxygen intake during the sedation. This oxygen monitoring is called pulse oximetry and is a valuable, continuous monitor of patient oxygenation.

Dosing of medications that produce conscious sedation is individualized, and the medication is administered slowly to gauge a patient’s response to the sedative. The two most common medications used to sedate patients for medical procedures are midazolam and fentanyl.

Fentanyl is a medication classified as an opioid narcotic analgesic (pain reliever) that is 50 to 100 times more potent than morphine. Given intravenously, the onset of action of fentanyl is almost immediate, and peak analgesia occurs with in 10 to 15 minutes. A single dose of fentanyl given intravenously can produce good analgesia for only 20 to 45 minutes for most patients because the drug’s distribution shifts from the brain (central nervous system) to peripheral tissues. The key to correct dosage is titration, or giving the medication in small amounts until the desired patient response is achieved.

Midazolam is a medication classified as a short-acting benzodiazepine (sedative) that depresses the central nervous system. Midazolam is ineffective for pain and has no analgesic effect during conscious sedation. The drug is a primary choice for conscious sedation because midazolam causes patients to have no recollection of the medical procedure. In general, midazolam has a fast-acting, short-lived sedative effect when given intravenously, achieving sedation within one to five minutes and peaking within 30 minutes. The effects of midazolam typically last one hour but may persist for six hours (including the amnestic effect). Patients who receive midazolam for conscious sedation should not be allowed to drive home after the procedure.

WHO PERFORMS THE PROCEDURE AND WHERE IS IT PERFORMED?

Conscious sedation is administered by medical or pediatric specialists performing a procedure that may be diagnostic and/or therapeutic. It may be used in a hospital, outpatient care facility, or doctor’s office.

Monitoring

Patient monitoring during conscious sedation must be performed by a trained and licensed health care professional. This clinician must not be involved in the procedure, but should have primary responsibility of monitoring and attending to the patient. Equipment must be in place and organized for monitoring the patien’s blood pressure, pulse, respiratoryrate, level of consciousness, and, most important, the oxygen saturation (the measure of oxygen perfusion inside the body) with a pulse oximeter (a machine that provides a continuous real-time recording of oxygenation). The oxygen saturation is the most sensitive parameter affected during increased levels of conscious sedation. Vital signs and other pertinent recordings must be monitored before the start of the administration of medications, and then at a minimum of every five minutes thereafter until the procedure is completed. After the procedure has been completed, monitoring should continue every 15 minutes for the first hour after the last dose of medication(s) was administered. After the first hour, monitoring can continue as needed. Children who receive sedative medication with a long half-life may require extended observation.

Risks and risk management

The American Academy of Pediatrics (AAP) has established safe practice guidelines to manage conscious sedation without an anesthesiologist for minor procedures. These AAP criteria include (1) a full-time licensed clinician (nurse, physician, physician assistant, surgeon assistant, respiratory therapist) who is strictly and exclusively monitoring the patient’s breathing, level of consciousness, vital signs, and airway; (2) standard procedures for monitoring vital signs; and (3) immediate availability (on site) of airway equipment, resuscitative medications, suction apparatus, and supplemental oxygen delivery systems.

QUESTIONS TO ASK THE DOCTOR

When should I stop taking my regular medications? When should I begin them again?

What side effects can I expect after the procedure? Nausea? Dizziness? Drowsiness? Is there anything I can do to ward off these side effects?

What are the risks of this procedure?

Which sedative will you use?

What steps will you take if there are complications?

Will I feel any pain?

If adverse reactions occur while using fentanyl, the antidote is a drug called naloxone. It provides rapid reversal of fentanyl’s narcotic effect. The incidence of oversedation or decreased respiration is low using fentanyl if the medication is carefully titrated.

Resources

BOOKS

Behrman, R. Nelson Textbook of Pediatrics, 16th ed. Philadelphia: W. B. Saunders Company, 2000.

PERIODICALS

U. S. Department of Health and Human Services. Acute Pain Management: Operative or Medical Procedures and Trauma. Clinical Practice Guidelines. Department of Health and Human Services Pub. No. AHCPR 92-0032.

The American Academy of Pediatrics and the American Academy of Pediatric Dentistry. Guidelines for Monitoring and Management of Pediatric Patients During and After Sedation for Diagnostic and Therapeutic Procedures. Clinical Guidelines Reference Manual. V29, no. 7 (2008). http://www.aapd.org/media/Policies_Guidelines/G_Sedation.pdf.

ORGANIZATIONS

American Association of Nurse Anesthetists. 222 South Prospect Avenue, Park Ridge, IL 60068-4001. (847) 692-7050 http://www.aana.com.

Laith Farid Gulli, M.D., M.S.

Alfredo Mori, MBBS

Renee Laux, M.S.

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