Bone Marrow Transplantation

Definition
Purpose
Demographics
Description
Diagnosis/Preparation
Aftercare
Risks
Normal results
Morbidity and mortality rates
Alternatives

Definition

The bone marrow—the sponge-like tissue found in the center of certain bones—contains stem cells that are the precursors of white blood cells, red blood cells, and platelets. These blood cells are vital for normal body functions, such as oxygen transport, defense against infection and disease, and clotting. Blood cells have a limited life span and are constantly being replaced; therefore, the production of healthy stem cells is vital.

In association with certain diseases, stem cells may produce too many, too few, or abnormal blood cells. Also, medical treatments may destroy stem cells or alter blood cell production. Blood cell abnormalities can be life threatening.

Bone marrow transplantation involves extracting bone marrow containing normal stem cells or peripheral stem cells from a healthy donor, and transferring it to a recipient whose body cannot manufacture proper quantities of normal blood cells. The goal of the transplant is to rebuild the recipient’s blood cells and immune system and hopefully cure the underlying disease.

Purpose

A person’s red blood cells, white blood cells, and platelets may be destroyed or may be abnormal due to disease. Also, certain medical therapies, particularly chemotherapy or radiation therapy, may destroy a person’s stem cells. The consequence to a person’s health is severe. Under normal circumstances, red blood cells carry oxygen throughout the body and remove carbon dioxide from the body’s tissues. White blood cells form the cornerstone of the body’s immune system and defend it against infection. Platelets limit bleeding by enabling the blood to clot if a blood vessel is damaged.

A bone marrow transplant is used to rebuild the body’s capacity to produce these blood cells and bring their numbers to normal levels. Illnesses that may be treated with a bone marrow transplant include both cancerous and non-cancerous diseases.

Cancerous diseases may or may not specifically involve blood cells; but, cancer treatment can destroy the body’s ability to manufacture new blood cells. Bone marrow transplantation may be used in conjunction with additional treatments, such as chemotherapy, for various types of leukemia, Hodgkin’s disease, lymphoma, breast and ovarian cancer, renal cell carcinoma, myelodysplasia, myelofibrosis, germ cell cancer, and other cancers. Non-cancerous diseases for which bone marrow transplantation can be a treatment option include aplastic anemia, sickle cell disease, thalassemia, and severe immunodeficiency.

Demographics

The decision to prescribe a bone marrow transplant is based on the patient’s age, general physical condition, diagnosis and stage of the disease. A person’s age or state of health may prohibit use of a bone marrow transplant. The typical cut-off age for a transplant ranges from 40 to 55 years; however, a person’s general health is usually the more important factor. Before undergoing a bone marrow transplant, the bone marrow transplant team will ensure that the patient understands the potential benefits and risks of the procedure.

The first successful bone marrow transplant took place in 1968 at the University of Minnesota. The recipient was a child with severe combined immunodeficiency disease and the donor was a sibling. In 1973, the first unrelated bone marrow transplant was performed at Memorial Sloan-Kettering Cancer Center in New York City on a five-year-old patient with severe combined immunodeficiency disease. In 1984, Congress passed the National Organ Transplant Act, which included language to evaluate unrelated marrow transplantation and determine if a national donor registry was feasible. The National Bone Marrow Donor Registry (NBMDR), now called the National Marrow Donor Program (NMDP), was established in 1986.

The NMDP Network has more than 10 million volunteer donors (6 million domestically, and another 4 million through its relationships worldwide) and has 43 donor centers and transplant centers in 16 countries.

Description

Types of bone marrow transplants

AUTOLOGOUS AND ALLOGENEIC TRANSPLANTS. Two important requirements for a bone marrow transplant are the donor and the recipient. Sometimes, the donor and the recipient may be the same person. This type of transplant is called an autologous transplant. It is typically used in cases in which a person’s bone marrow is generally healthy but will be destroyed due to medical treatment for diseases such as breast cancer and Hodgkin’s disease. Autologous transplants are also possible if the disease affecting the bone marrow is in remission. If a person’s bone marrow is unsuitable for an autologous transplant, the bone marrow must be derived from another person in an allogeneic transplant.

An allogeneic bone marrow donor may be a family member or an unrelated donor. The donated bone marrow/peripheral stem cells must perfectly match the patient’s bone marrow. The matching process is called human leukocyte antigens (HLA). Antigens are markers

KEY TERMS

ABO antigen— Protein molecules located on the surfaces of red blood cells that determine a person’s blood type: A, B, or O.

Acute myelogenous leukemia (AML)— Also called acute myelocytic leukemia, a malignant disorder where myeloid blast cells accumulate in the marrow and bloodstream.

Allogeneic— Referring to bone marrow transplants between two different, genetically dissimilar people.

Anemia— Decreased red cell production that results in a deficiency in oxygen-carrying capacity of the blood.

Antigen— A molecule that is capable of provoking an immune response.

Aplastic anemia— A disorder in which the body produces inadequate amounts of red blood cells and hemoglobin due to underdeveloped or missing bone marrow.

Autologous— Referring to bone marrow transplants in which recipients serve as their own donors.

Blank— If an individual has inherited the same HLA antigen from both parents, the HLA typing is designated by the shared HLA antigen followed by a “blank” (-).

Blast cells— Blood cells in early stage of cellular development.

Blast crisis— Stage of chronic myelogenous leukemia where large quantities of immature cells are produced by the marrow, and it is not responsive to treatment.

Bone marrow— A spongy tissue located within flat bones, including the hip and breast bones and the skull. This tissue contains stem cells, the precursors of platelets, red blood cells, and white blood cells.

Bone marrow biopsy— A test involving the insertion of a thin needle into the breastbone or, more commonly, the hip, in order to aspirate (remove) a sample of the marrow. A small piece of cortical bone may also be obtained for biopsy.

Bone marrow transplant— Healthy marrow is infused into people who have had high-dose chemotherapy for one of the many forms of leukemias, immunodeficiencies, lymphomas, anemias, metabolic disorders, and sometimes solid tumors.

Chemotherapy— Medical treatment of a disease, particularly cancer, with drugs or other chemicals.

Chest x ray— A diagnostic procedure in which a very small amount of radiation is used to produce an image of the structures of the chest (heart, lungs, and bones) on film.

Chronic myelogenous leukemia (CML)— Also called chronic myelocytic leukemia, a malignant disorder that involves abnormal accumulation of white cells in the marrow and bloodstream.

Cytomegalovirus (CMV)— Virus that can cause pneumonia in post bone marrow transplant patients.

Computed tomography scan (CT or CAT)— Computed axial tomography uses x rays and computers to produce an image of a cross-section of the body.

Conditioning— Process of preparing a patient to receive marrow donation, often through the use of chemotherapy and radiation therapy.

Confirmatory typing— Repeat tissue typing to confirm the compatibility of the donor and patient before transplant.

Donor— A healthy person who contributes bone marrow for transplantation.

Echocardiogram— An imaging procedure used to create a picture of the heart’s movement, valves and chambers. The test uses high-frequency sound waves that come from a hand wand placed on the chest. Echocardiogram may be used in combination with Doppler ultrasound to evaluate the blood flow across the heart’s valves.

Electrocardiogram (ECG, EKG)— A test that records the electrical activity of the heart using small electrode patches attached to the skin on the chest.

Graft versus host disease— A life-threatening complication of bone marrow transplants in which the donated marrow causes an immune reaction against the recipient’s body.

Histocompatibility— The major histocompatibility determinants are the human leukocyte antigens (HLA), and characterize how well the patient and donor are matched.

Human leukocyte antigen (HLA)— A group of protein molecules located on bone marrow cells that can provoke an immune response. A donor’s and a recipient’s HLA types should match as closely as possible to prevent the recipient’s immune system from attacking the donor’s marrow as a foreign material that does not belong in the body.

Hodgkin’s disease— A type of cancer involving the lymph nodes and potentially affecting non-lymphatic organs in the later stage.

Immunodeficiency— A disorder in which the immune system is ineffective or disabled due either to acquired or inherited disease.

Leukemia— A type of cancer that affects leukocytes, a particular type of white blood cell. A characteristic symptom is excessive production of immature or otherwise abnormal leukocytes.

Lymphoma— A type of cancer that affects lymph cells and tissues, including certain white blood cells (T cells and B cells), lymph nodes, bone marrow, and the spleen. Abnormal cells (lymphocyte/leukocyte) multiply uncontrollably.

Match— How similar the HLA typing, out of a possible six antigens, is between the donor and the recipient.

Mixed lymphocyte culture (MLC)— Test that measures level of reactivity between donor and recipient lymphocytes.

Myelodysplasia— Also called myelodysplastic syndrome, it is a condition in which the bone marrow does not function normally and can affect the various types of blood cells produced in the bone marrow. Often referred to as a preleukemia and may progress and become acute leukemia.

Myelofibrosis— An anemic condition in which bone marrow cells are abnormal or defective and become fibrotic.

Neuroblastoma— Solid tumor in children, may be treated by BMT.

Non-myeloablative allogeneic bone marrow transplant— Also called “mini” bone marrow transplants. This type of bone marrow transplant involves receiving low-doses of chemotherapy and radiation therapy, followed by the infusion of a donor’s bone marrow or peripheral stem cells. The goal is to suppress the patient’s own bone marrow with low-dose chemotherapy and radiation therapy to allow the donor’s cells to engraft.

Peripheral stem cells— Stem cells that are taken directly from the circulating blood and used for transplantation. Stem cells are more concentrated in the bone marrow, but they can also be extracted from the bloodstream.

Peripheral stem cell transplant— The process of transplanting peripheral stem cells instead of using bone marrow. The stem cells in the circulating blood that are similar to those in the bone marrow are given to the patient after treatment to help the bone marrow recover and continue producing healthy blood cells. A peripheral stem cell transplant may also be used to supplement a bone marrow transplant.

Platelets— Fragments of a large precursor cell, a megakaryocyte found in the bone marrow. These fragments adhere to areas of blood vessel damage and release chemical signals that direct the formation of a blood clot.

Pulmonary function test— A test that measures the capacity and function of the lungs, as well as the blood’s ability to carry oxygen.

Radiation therapy— The use of high-energy radiation from x rays, cobalt, radium, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external beam radiation therapy) or from materials called radioisotopes. Radioisotopes produce radiation and are placed in or near the tumor or in the area near the cancer cells. This type of radiation treatment is called internal radiation therapy, implant radiation, interstitial radiation, or brachytherapy. Systemic radiation therapy uses a radioactive substance, such as a radio-labeled monoclonal antibody that circulates throughout the body.

Recipient— The person who receives the donated blood marrow.

Red blood cells— Cells that carry hemoglobin (the molecule that transports oxygen) and help remove wastes from tissues throughout the body.

Remission— Disappearance of the signs and symptoms of cancer. When this happens, the disease is said to be “in remission.” A remission can be temporary or permanent.

Sickle cell disease— An inherited disorder characterized by a genetic flaw in hemoglobin production. (Hemoglobin is the substance within red blood cells that enables them to transport oxygen.) The hemoglobin that is produced has a kink in its structure that forces the red blood cells to take on a sickle shape, inhibiting their circulation and causing pain. This disorder primarily affects people of African descent.

Stem cells— Unspecialized cells, or “immature” blood cells, that serve as the precursors of white blood cells, red blood cells, and platelets.

Syngeneic— Referring to a bone marrow transplant from one identical twin to the other.

Thalassemia— A group of inherited disorders that affects hemoglobin production. Because hemoglobin production is impaired, a person with this disorder may suffer mild to severe anemia. Certain types of thalassemia can be fatal.

Umbilical cord blood transplant— A procedure in which the blood from a newborn’s umbilical cord, which is rich in stem cells, is used as the donor source for bone marrow transplants. Currently, umbilical cord blood transplants are mainly used for sibling bone marrow transplants or to store blood for an anonymous donation. In most cases, umbilical cord blood does not contain enough stem cells to safely use for adult bone marrow transplants.

White blood cells— A group of several cell types that occur in the bloodstream and are essential for a properly functioning immune system.

in cells that stimulate antibody production. HLA antigens are proteins on the surface of bone marrow cells. HLA testing is a series of blood tests that evaluate the closeness of tissue between the donor and recipient. If the donor and the recipient have very dissimilar antigens, the recipient’s immune system regards the donor’s bone marrow cells as invaders and launches a destructive attack against them. Such an attack negates any benefits offered by the transplant.

NON-MYELOABLATIVE (“MINI”) ALLOGENEIC TRANSPLANTS. A “mini” transplant involves receiving low-doses of chemotherapy and radiation therapy, followed by the infusion of a donor’s bone marrow or peripheral stem cells. The goal is to suppress the patient’s own bone marrow with low-dose chemotherapy and radiation therapy to allow the donor’s cells to engraft. If there are cancer cells remaining in the body, the donated cells are able to identify the cancer cells as foreign and trigger an immune response, killing the cancer cells. This is called the graft-versus-tumor effect. Mini transplants are still under investigation, but are promising for the future.

PERIPHERAL BLOOD STEM CELL TRANSPLANTS. A relatively recent development in stem cell transplantation is the use of peripheral blood stem cells instead of cells from the bone marrow. Peripheral blood stem cells (PBSCs) are obtained from circulating blood rather than from bone marrow, but the amount of stem cells found in the peripheral blood is much smaller than the amount of stem cells found in the bone marrow. Peripheral blood stem cells can be used in either autologous or allogeneic transplants. The majority of PBSC transplants are autologous. However, clinical studies indicate that PBSCs are being used more frequently than bone marrow for allogeneic bone marrow transplantation.

The advantages of PBSC transplants when compared to bone marrow transplants are that, in allogeneic transplantation, hematopoietic and immune recovery are faster with PBSCs. In autologous transplantation, the use of PBSCs can result in faster blood count recovery. Also, some medical conditions exist in which the recipient cannot accept bone marrow transplants, but can accept PBSC transplants. A possible disadvantage to PBSC transplant versus bone marrow transplantation is that so much more fluid volume is necessary to collect enough PBSCs that, at the time that the new stem cells are infused into the recipient, the fluid can collect in the lungs. Also, the time commitment for the donor for a PBSC transplant is considerable. When the PBSCs are being collected, several outpatient sessions are needed and each session lasts approximately between two and four hours.

UMBILICAL CORD BLOOD TRANSPLANT. Umbilical cord blood transplant is a relatively new procedure in which umbilical cord blood from a newborn is used as the donor source. Umbilical cord blood is rich in stem cells, the cells that are needed for transplantation, and these cells are theoretically “immunologically naive,” reducing chances of rejection and making it a good source for donation. The matching criteria are the same as for bone marrow. Most programs to date use this procedure for a sibling or store cord blood for anonymous donation. Umbilical cord blood can be an excellent source for children. One potential problem with umbilical cord blood transplantation is the low volume of stem cells contained in the umbilical cord. In many instances, there is inadequate volume to safely use for a transplant in an adult recipient.

The transplant procedure

HLA MATCHING. There are only five major HLA classes or types—designated HLA-A, -B, -C, -D, and class III—but much variation within the groupings. For example, HLA-A from one individual may be similar to, but not the same as, HLA-A in another individual; such a situation can render a transplant from one to the other impossible.

HLA matching is more likely if the donor and recipient are related, particularly if they are siblings; however, an unrelated donor may be a potential match. The only case in which matching HLA types between two people is not an issue is if the recipient has an identical twin. Identical twins carry the same genes, therefore, the same antigens. A bone marrow transplant between identical twins is called a syngeneic transplant.

BONE MARROW TRANSPLANTATION. The bone marrow extraction, or harvest, is the same for autologous and allogeneic transplants. Harvesting is done under general anesthesia, and discomfort is usually minimal afterwards. Bone marrow is drawn from the iliac crest (the part of the hip bone on either side of the lower back) with a special needle and a syringe. Several punctures are usually necessary to collect the needed amount of bone marrow, approximately 1–2 quarts. (This amount is only a small percentage of the total bone marrow and is typically replaced within four weeks.) The donor remains at the hospital for 24–48 hours and can resume normal activities within a few days.

If the bone marrow is meant for an autologous transplant, it is stored at -112–-320°F (-80–-196°C) until it is needed. If a patient’s own bone marrow can be used for transplantation or if a donor is not found, peripheral stem cells may be harvested from the patient’s circulating blood. Bone marrow for an allogeneic transplant is sometimes treated to remove the donor’s T cells (a type of white blood cell) or to remove ABO (blood type) antigens; otherwise, it is transplanted without modification.

The bone marrow or peripheral stem cells are administered to the recipient via a catheter (a narrow, flexible tube) inserted into a large vein in the chest. The donor cells look like a bag of blood and are infused for about 20-30 minutes. During the infusion, the patient’s blood pressure, pulse, and breathing are monitored. From the bloodstream, the marrow migrates to the cavities within the bones where bone marrow is normally stored. If the transplant is successful, the bone marrow begins to produce normal blood cells once it is in place, or engrafted.

PERIPHERAL BLOOD STEM CELL TRANSPLANTATION. Before collection for a PBSC transplant, donors receive four injections daily of the drug G-CSF, or filgrastim. (Patients can give it to themselves at home, if necessary.) These pretreatments stimulate the body to release stem cells into the blood. After these pretreatments, the donors’ experience is similar to that of a whole blood donor’s experience—PBSC donor’s blood is collected at a clinic or hospital as an outpatient procedure. The differences are that several sessions will be needed over days or weeks, and the blood is collected in a process called apheresis. The blood travels from one arm into a blood cell separator that removes only the stem cells, and the rest of the blood is returned back to the donor in the other arm. The cells are then frozen for later use.

The PBSCs are administered to the recipient using the same methods as those used in bone marrow transplantation. As stated, the amount of fluid with PBSCs infused into the recipient’s body can be an issue.

Costs

Bone marrow transplantation is an expensive procedure. (Bone marrow donors are volunteers and do not pay for any part of the procedure.) Insurance companies and health maintenance organizations (HMOs) may not cover the costs. Many insurance companies require precertification letters of medical necessity. As soon as bone marrow transplantation is discussed as a treatment option, it is important for the patient to contact his or her insurance provider to determine what costs will be covered.

Diagnosis/Preparation

Several tests are performed before the bone marrow transplant to identify any potential problems ahead of time. Tests include:

• tissue typing and a variety of blood tests
• chest x ray
• pulmonary function tests
• computed tomography scan (CT or CAT)
• heart function tests, including an electrocardiogram and echocardiogram
• bone marrow biopsy
• skeletal survey

In addition, a complete dental exam is needed before the bone marrow transplant to reduce the risk of infection. Other precautions will be taken before the transplant to reduce the patient’s risk of infection.

A triple lumen, central venous catheter (a slender, hollow flexible tube) is surgically inserted into a large vein in the chest during a simple outpatient procedure. The catheter is used to draw blood and infuse chemotherapy and other medications, as well as donor cells, blood product, fluids, and sometimes nutritional solutions. The central venous catheter usually stays in place for about six months after the bone marrow transplant.

Hormone-like medications called colony-stimulating factors may be given before the transplant to stimulate the patient’s white blood cells. These medications stimulate the white blood cells to multiply, mature, and function. These medications also help the patient’s white blood cells recover from chemotherapy and reduce the risk of infection.

A bone marrow transplant recipient can expect to spend three to four weeks in the hospital, depending on the rate of recovery. In preparation for receiving the transplant, the recipient undergoes “conditioning,” a preparative regimen (also called marrow ablation) in which the bone marrow and abnormal cells are destroyed. Conditioning rids the body of diseased cells and makes room for the marrow or peripheral stem cells to be transplanted. It typically involves chemotherapy and/or radiation treatment, depending on the disease being treated. Unfortunately, this treatment also destroys healthy cells and has many side effects such as extreme weakness, nausea, vomiting, and diarrhea. These side effects may continue for several weeks.

Aftercare

A two- to four-week waiting period follows the marrow transplant before its success can begin to be evaluated. The marrow recipient is kept in isolation during this time to minimize potential infections. The recipient also receives intravenous antibiotic, antiviral, and antifungal medications, as well as blood and platelet transfusions to help fight off infection and prevent excessive bleeding. Blood tests are performed daily to monitor the patient’s kidney and liver function, as well as nutritional status. Other tests are performed as necessary. Further side effects, such as nausea and vomiting, can be treated with other medications. Once blood counts are normal and the side effects of the transplant abate, the recipient is taken off antibiotics and usually no longer needs blood and platelet transfusions.

Following discharge from the hospital, the recipient is monitored through home visits by nurses or outpatient visits for up to a year. For the first several months out of the hospital, the recipient needs to be careful in avoiding potential infections. For example, contact with other people who may be ill should be avoided or kept to a minimum. Further blood transfusions and medications may be necessary, but barring complications, the recipient can return to normal activities about six to eight months after the transplant.

Risks

The procedure has a lower success rate the greater the recipient’s age. Complications are exacerbated for people whose health is already seriously impaired, as in late-stage cancers.

Bone marrow transplants are accompanied by serious and life-threatening risks. Furthermore, they are not always an absolute assurance of a cure for the underlying ailment; a disease may recur in the future.

Even in the absence of complications, the transplant and associated treatments are hard on the recipient. Bone marrow transplants are debilitating. A person’s ability to withstand the rigors of the transplant is a key consideration in deciding to use this treatment.

In the short term, there is the danger of pneumonia or other infectious disease, excessive bleeding, or liver disorder caused by blocked blood vessels. The transplant may be rejected by the recipient’s immune system, or the donor bone marrow may launch an immune-mediated attack against the recipient’s tissues. This complication is called acute graft-versus-host disease, and it can be a life-threatening condition. Characteristic signs of the disease include fever, rash, diarrhea, liver problems, and a compromised immune system.

Approximately 25-50% of bone marrow transplant recipients develop long-term complications. Chronic graft-versus-host disease symptoms include skin changes, such as dryness, altered pigmentation, and thickening, abnormal liver function tests, dry mouth and eyes, infections, and weight loss. Other long-term complications include cataracts (due to radiation treatment), abnormal lung function, hormonal abnormalities resulting in reduced growth or hypothyroidism, secondary cancers, and infertility.

Normal results

In a successful bone marrow transplant, the donor’s marrow migrates to the cavities in the recipient’s bones and produces normal numbers of healthy blood cells. Bone marrow transplants can extend a person’s life, improve quality of life, and may aid in curing the underlying ailment.

Morbidity and mortality rates

Approximately 30% of people receiving allogeneic transplants do not survive. Autologous transplants have a much better survival rate—nearly 90%—but are not appropriate for all types of ailments requiring a bone marrow transplant. Furthermore, autologous transplants have a higher failure rate with certain diseases, specifically leukemia. At two years, the survival rate for patients with chronic myelogenous leukemia is 52% if they received a transplant in a chronic phase of their disease, 30% for patients in an accelerated phase and 15% for patients in the blast phase.

Alternatives

Complementary therapies are used along with standard cancer treatments. These treatments are aimed at bringing about some overall improvement in general health and well being. Complementary therapies can be helpful in managing symptoms and improving quality of life. They can be used to help alleviate pain; reduce nausea; strengthen muscles; and decrease depression, anxiety, and stress. It is

WHO PERFORMS THIS PROCEDURE AND WHERE IS IT PERFORMED?

Transplant physicians specially trained in bone marrow transplantation should perform this procedure. Bone marrow transplant physicians have extensive experience in hematology/oncology and bone marrow transplant.

Selecting a transplant center that has a multidisciplinary team of specialists is important. The bone marrow transplant team should include transplant physicians, infectious disease specialists, pharmacologists, registered nurses, and transplant coordinators. Other transplant team members may include registered dietitians, social workers, and financial counselors.

When selecting a transplant center, the patient should find out where the center is accredited. Some examples of accrediting organizations include The Foundation for the Accreditation of Cellular Therapy, the American Association of Blood Banking, the National Marrow Donor Program, and other state-level accreditation organizations.

Choosing a transplant center with experience is important. Here are some questions to consider when choosing a transplant center:

• How many bone marrow transplants are performed annually, and what are the outcomes/survival rates of those transplants?
• Does the transplant center perform transplants for the patient’s type of disease? How many has it performed to date?
• Does the transplant center have experiencetreating patients the same age as the patientconsidering transplant?
• What is the required patient and unrelated donor HLA matching level at this center?
• How much does a typical bone marrow transplant cost at this facility?
• Is financial help available?
• If the transplant center is far from the patient’s home, will accommodations be provided for caregivers?

important to distinguish between alternative therapies (unproven methods promoted for use instead of mainstream treatment) and complementary therapies, which are used with standard treatment. Complementary therapies are noninvasive and soothing. However, before trying them, patients should check with their oncologist to make sure the complementary therapy will not interfere with standard cancer therapy or cause harm. Examples of complementary therapies are massage therapy, aromatherapy, meditation, yoga, biofeedback, music, art and dance therapies, and group and individual therapy or counseling.

Hormone therapy is the treatment of cancer by removing, blocking, or adding hormones. Hormones are chemical substances produced by glands in the body that enter the bloodstream and cause effects in other tissues. Hormone therapies may be used to treat breast and prostate cancers. Hormone therapy may also be used in some situations for other cancers.

Immunotherapy, also called biological therapy, is a type of treatment that uses the body’s immune system to fight cancer. The therapy mainly consists of stimulating the immune system with highly purified proteins that help it do its job more effectively.

Radiation therapy is the use of high-energy x rays, electron beams, or radioactive isotopes to attack cancer. Radiation therapy causes cancer cell death by ionization or by damaging the chromosomes in the cancer cells so they cannot multiply. Radiation therapy is a local treatment aimed directly at the cancer. Even though the radiation is aimed only at the cancer, it must often pass through skin and other organs to reach the tumor. Thus, some healthy cells may become damaged, too. The body however is able to repair the healthy cells that have been damaged and restore them to their proper function. Aside from its use as a single treatment, radiation therapy has been shown to enhance the effects of chemotherapy. It can be used in combination with chemotherapy to shrink a tumor. Successful radiation therapy depends on delivering the proper amount of radiation to the cancer in the best, and most effective way.

Resources

BOOKS

Abeloff, M. D., et al.Clinical Oncology. 3rd ed. Philadelphia: Elsevier, 2004.

Khatri, V. P., and J. A. Asensio. Operative Surgery Manual. 1st ed. Philadelphia: Saunders, 2003.

Townsend, C. M., et al. Sabiston Textbook of Surgery. 17th ed. Philadelphia: Saunders, 2004.

ORGANIZATIONS

American Cancer Society. 1599 Clifton Road, NE, Atlanta, GA 30329. (800) 227-2345, (404) 320-3333. http://www.cancer.org (accessed March 7, 2008).

QUESTIONS TO ASK THE DOCTOR

• What type of transplant is recommended for my condition?
• What are the potential benefits of bone marrow transplantation?
• Where does transplanted bone marrow come from?
• What types of tests are required to screen me for the bone marrow transplant?
• What is HLA/histocompatibility matching?
• What types of tests are used to screen potential bone marrow or peripheral stem donors?
• Are bone marrow or peripheral stem cell donors compensated?
• After my bone marrow transplant, can I contact an unrelated donor? How can I do this?
• Will my insurance provider cover the expenses of my bone marrow transplant?
• What types of questions should I ask my insurance provider to determine if the medical expenses of my bone marrow transplant will be covered?
• Whose insurance covers the medical expenses of the donor?
• How long does the insurance clearance process take?
• After bone marrow transplantation is approved as a treatment option for me, how long will I have to wait before I can receive the bone marrow transplant?
• What type of preparative regimen will I have before the bone marrow transplant?
• What are the side effects of the preparative regimen?
• What types of precautions must I follow before and after my bone marrow transplant?
• Will I have to have blood transfusions during the transplantation process?
• What are the risks and potential complications of bone marrow transplantation?
• What is Graft-versus-Host disease (GVHD) and can it be prevented?
• What are the signs of GVHD, rejection, and infection?
• How and when will I know if the bone marrow transplant was successful?
• How long will I have to stay in the hospital?
• What types of resources are available to me during my hospital stay and during my recovery at home?
• What types of medications will I have to take after my bone marrow transplant? How long will I have to take them?
• After I go home, when can I resume my normal activities?
• What type of follow-up care is recommended? How often will I need to go to follow-up appointments?
• Can I receive follow-up care from my primary physician, or do I need to go back to the center where I had my bone marrow transplant?
• If I live far away from my transplant center, do I have to stay near the transplant center during my recovery after discharge? If yes, for how long? Will I receive help in making accommodations?

American Society for Blood and Marrow Transplantation (ASBMT). 85 W. Algonquin Road, Suite 550 Arlington Heights, IL 60005. (847) 427-0224. [email protected].

BMT Infonet (Blood and Marrow Transplant Information Network). 2900 Skokie Valley Road, Suite B, Highland Park, IL 60035. (847) 433-3313, (888) 597-7674. [email protected]. http://www.bmtinfonet.org (accessed March 7, 2008).

Cancercare. Health Resources and Services Administration. 5600 Fishers Lane, Rm. 14-45, Rockville, MD 20857. (301) 443-3376. (800) 813-HOPE (4673). http://www.cancercare.org (accessed March 7, 2008).

International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry N. America. Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226. (414) 456-8325. [email protected].

Leukemia & Lymphoma Society, Inc. 1311 Mamaroneck Avenue White Plains, NY 10605. (914) 949-5213. http://www.leukemia-lymphoma.org (accessed March 7, 2008).

Lymphoma Research Foundation of America. 8800 Venice Boulevard, Suite 207, Los Angeles, CA 90034. (800) 500-9976. (310) 204-7040. [email protected]. http://www.lymphoma.org (accessed March 7, 2008).

National Bone Marrow Transplant Link. 20411 W. 12 Mile Road, Suite 108, Southfield, MI 48076. (800) LINK-BMT (800-546-5268).

National Foundation for Transplants. 1102 Brookfield, Suite 200, Memphis, TN, 38110. (800) 489-3863 or (901) 684-1697. http://www.transplants.org (accessed March 7, 2008).

National Marrow Donor Program. Suite 500, 3001 Broadway Street Northeast, Minneapolis, MN 55413-1753. (800) MARROW-2. http://www.marrow.org (accessed March 7, 2008).

National Organ and Tissue Donation Initiative. http://www.organdonor.gov (accessed March 7, 2008).

Julia Barrett

Laura Ruth, PhD

Angela M. Costello

Rosalyn Carson-DeWitt, MD

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