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Precocious Puberty

Precocious puberty

Definition

Precocious puberty is sexual development before the age of eight in girls, and age 10 in boys.

Description

Precocious puberty often begins before age eight in girls, triggering the development of breasts and hair under the arms and in the genital region. The onset of ovulation and menstruation also may occur. In boys, the condition triggers the development of a large penis and testicles, with spontaneous erections and the production of sperm. Hair grows on the face, under arms and in the pubic area, and acne may become a problem.

While the early onset of puberty may seem fairly benign, in fact it can cause problems when hormones trigger changes in the growth pattern, essentially halting growth before the child has reached normal adult height. Girls may never grow above 5 ft (152 cm) and boys often stop growing by about 5 ft 2 in (157 cm).

The abnormal growth patterns are not the only problem, however. Children with this condition look noticeably different than their peers, and may feel rejected by their friends and socially isolated. Adults may expect these children to act more maturely simply because they look so much older. As a result, many of these children, especially boys, are much more aggressive than others their own age, leading to behavior problems both at home and at school.

Demographics Not every child reaches puberty at the same time, but in most cases it is safe to predict that sexual development will begin at about age 11 in girls and 12 or 13 in boys. However, occasionally a child begins to develop sexually much earlier. Between four to eight times more common in girls than boys, precocious puberty occurs in one out of every 5,00010,000 U.S. children.

Causes and symptoms Puberty begins when the brain secretes a hormone that triggers the pituitary gland to release gonadotropins, which in turn stimulate the ovaries or testes to produce sex hormones. These sex hormones (especially estrogen in girls and testosterone in boys) are what causes the onset of sexual maturity.

The hormonal changes of precious puberty are normalit is just that the whole process begins a few years too soon. Especially in girls, there is not usually any underlying problem that causes the process to begin too soon. However, some boys do inherit the condition; the responsible gene may be passed directly from father to son, or inherited indirectly from the maternal grandfather through the mother, who does not begin early puberty herself. This genetic condition in girls can be traced in only about one percent of cases.

In about 15 percent of cases, there is an underlying cause for the precocious puberty, and it is important to search for these causes. The condition may result from a benign tumor in the part of the brain that releases hormones. Less commonly, it may be caused by other types of brain tumors, central nervous system disorders, or adrenal gland problems.

When to call the doctor

A pediatrician should be consulted when girls under age eight start to show signs breast development and menstruation, or if boys under age 10 show enlarged genitals and body hair.

Diagnosis

Physical exams can reveal the development of sexual characteristics in a young child. Bone x rays can reveal bone age, and pelvic ultrasound may show an enlarged uterus and rule out ovarian or adrenal tumors. Blood tests can highlight higher-than-normal levels of hormones. MRI or CAT scans should be considered to rule out intracranial tumors.

Treatment

Treatment aims to halt or reverse sexual development so as to stop the accompanying rapid growth that will limit a child's height. There are two possible approaches: either treat the underlying condition (such as an ovarian or intracranial tumor) or change the hormonal balance to stop sexual development. It may not be possible to treat the underlying condition; for this reason, treatment is usually aimed at adjusting hormone levels.

There are several drugs that have been developed to do this:

  • histrelin (Supprelin)
  • nafarelin (Synarel)
  • synthetic gonadotropin-releasing hormone agonist
  • deslorelin
  • ethylamide
  • triptorelin
  • leuprolide

Prognosis

Drug treatments can slow growth to 23 in (57.5 cm) a year, allowing these children to reach normal adult height, although the long-term effects are not known.

Prevention

There is no way to prevent precocious puberty.

KEY TERMS

Puberty The point in development when the ability to reproduce begins. The gonads begin to function and secondary sexual characteristics begin to appear.

Parental concerns

Support and appropriate treatment of any underlying medical disorders are appropriate for parents. The vast majority of children experiencing precocious puberty become lost in the crowd of their peers when their age peers enter puberty. Counseling may be useful for both parents and affected child.

Resources

BOOKS

Garibaldi, Luuigi. "Disorders of Pubertal Development." In Nelson Textbook of Pediatrics. 17th ed. Ed. by Richard E. Behrman, et al., Philadelphia: Saunders, 2003, 1863-9.

New, Maria and Josso, Nathalie. "Disorders of Sexual Diferentiation." In Cecil Textbook of Medicine. 22nd ed. Ed. by Lee Goldman, et al. Philadelphia: Saunders, 2003, 1163-71.

PERIODICALS

Carel, J.C., et al. "Precocious puberty and statural growth." Human Reproduction Update 10, no. 2 (2004): 135-47.

Grosso, S., et al. "Central precocious puberty and abnormal chromosomal patterns." Endocrine Pathology 11, no. 1 (2004): 69-76.

Kaplowitz, P. "Clinical characteristics of 104 children referred for evaluation of precocious puberty." Journal of Clinical Endocrinology and Metabolism 89, no. 8 (2004): 3644-50.

Lanes, R., Soros, A., and Jakubowicz, S. "Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty." Journal of Pediatric Endocrinology and Metabolism 17, no. 5 (2004): 759-66.

L. Fleming Fallon, Jr., MD, DrPH

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Precocious Puberty

Precocious Puberty

Definition

Sexual development before the age of eight in girls, and age 10 in boys.

Description

Not every child reaches puberty at the same time, but in most cases it's safe to predict that sexual development will begin at about age 11 in girls and 12 or 13 in boys. However, occasionally a child begins to develop sexually much earlier. Between four to eight times more common in girls than boys, precocious puberty occurs in one out of every 5,000 to 10,000 U.S. children.

Precocious puberty often begins before age 8 in girls, triggering the development of breasts and hair under the arms and in the genital region. The onset of ovulation and menstruation also may occur. In boys, the condition triggers the development of a large penis and testicles, with spontaneous erections and the production of sperm. Hair grows on the face, under arms and in the pubic area, and acne may become a problem.

While the early onset of puberty may seem fairly benign, in fact it can cause problems when hormones trigger changes in the growth pattern, essentially halting growth before the child has reached normal adult height. Girls may never grow above 5 ft (152 cm) and boys often stop growing by about 5 ft 2 in (157 cm).

The abnormal growth patterns are not the only problem, however. Children with this condition look noticeably different than their peers, and may feel rejected by their friends and socially isolated. Adults may expect these children to act more maturely simply because they look so much older. As a result, many of these children-especially boys-are much more aggressive than others their own age, leading to behavior problems both at home and at school.

Causes and symptoms

Puberty begins when the brain secretes a hormone that triggers the pituitary gland to release gonadotropins, which in turn stimulate the ovaries or testes to produce sex hormones. These sex hormones (especially estrogen in girls and testosterone in boys) are what causes the onset of sexual maturity.

The hormonal changes of precious puberty are normal-it's just that the whole process begins a few years too soon. Especially in girls, there is not usually any underlying problem that causes the process to begin too soon. However, some boys do inherit the condition; the responsible gene may be passed directly from father to son, or inherited indirectly from the maternal grandfather through the mother, who does not begin early puberty herself. This genetic condition in girls can be traced in only about 1% of cases.

In about 15% of cases, there is an underlying cause for the precocious puberty, and it is important to search for these causes. The condition may result from a benign tumor in the part of the brain that releases hormones. Less commonly, it may be caused by other types of brain tumors, central nervous system disorders, or adrenal gland problems.

Diagnosis

Physical exams can reveal the development of sexual characteristics in a young child. Bone x rays can reveal bone age, and pelvic ultrasound may show an enlarged uterus and rule out ovarian or adrenal tumors. Blood tests can highlight higher-than-normal levels of hormones. MRI or CAT scans should be considered to rule out intracranial tumors.

Treatment

Treatment aims to halt or reverse sexual development so as to stop the accompanying rapid growth that will limit a child's height. There are two possible approaches: either treat the underlying condition (such as an ovarian or intracranial tumor) or change the hormonal balance to stop sexual development. It may not be possible to treat the underlying condition; for this reason, treatment is usually aimed at adjusting hormone levels.

There are several drugs that have been developed to do this:

  • histrelin (Supprelin)
  • nafarelin (Synarel)
  • synthetic gonadotropin-releasing hormone agonist
  • deslorelin
  • ethylamide
  • triptorelin
  • leuprolide

Prognosis

Drug treatments can slow growth to 2-3 in (5-7.5 cm) a year, allowing these children to reach normal adult height, although the long-term effects aren't known.

Resources

ORGANIZATIONS

National Institute of Child Health and Human Development. Bldg 31, Room 2A32, MSC 2425, 31 Center Drive, Bethesda, MD 20892-2425. (800) 505-2742. http://www.nichd.nih.gov/sids/sids.htm.

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precocious puberty

precocious puberty (pri-koh-shŭs) n. the development in girls of breasts or pubic hair before the age of six or menstruation before the age of eight, and in boys the development of pubic hair or other adult sexual features below the age of nine. In girls 90% of cases have no underlying abnormalities, but in boys approximately half have a serious underlying cause, of which malignant testicular or adrenal tumours are the most common.

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"precocious puberty." A Dictionary of Nursing. . Encyclopedia.com. 20 Feb. 2018 <http://www.encyclopedia.com>.

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Notes:
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