proton-pump inhibitor (proh-ton-pump) n. a drug that reduces gastric acid secretion by blocking an enzyme (the proton pump) within the oxyntic (parietal) cells of the gastric glands. Proton-pump inhibitors include omeprazole, lansoprazole, and rabeprazole; they are used for treating gastric and duodenal ulcers, reflux oesophagitis, and the hypersecretion caused by gastrinomas.
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