potassium-channel activator n. a drug that enhances the movement of potassium ions through the protein channels in cell membranes, reducing the sensitivity of smooth muscle cells in the walls of arteries to the normal stimuli to contract. The result is widening of the arteries. Potassium-channel activators, such as nicorandil (Ikorel), are used for improving the blood supply to the heart muscle in angina pectoris.
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