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hypercalcaemia (hy-per-kal-see-miă) n. the presence in the blood of an abnormally high concentration of calcium. The many causes include excessive ingestion of vitamin D, overactivity of the parathyroid glands, and malignant disease. It may also occur in association with other symptoms as a congenital condition. malignant h. hypercalcaemia resulting from the secretion by a tumour of substances that stimulate bone resorption or from bone metastases causing localized destruction and release of calcium into the bloodstream.