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chloroquine (klo-roh-kween) n. a drug used principally in the treatment and prevention of benign malarias but also used in the treatment of rheumatoid arthritis and lupus erythematosus. It is administered by mouth or injection; a side-effect of prolonged use in large doses is eye damage. Trade names:. Avloclor,. Malarivon,. Nivaquine.