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vitiate •labiate •irradiate, radiate •mediate • ideate • repudiate •palliate, retaliate •affiliate, ciliate, conciliate, humiliate •exfoliate, foliate •nucleate • permeate • delineate •calumniate • expiate •expatriate, repatriate •recreate • inebriate •aureate, excoriate •procreate •appropriate, expropriate, impropriate, misappropriate •infuriate, luxuriate •asphyxiate • nauseate •annunciate, enunciate •instantiate, substantiate, transubstantiate •differentiate, potentiate •expatiate, ingratiate, satiate •appreciate, depreciate •initiate, officiate, propitiate, vitiate •associate, dissociate, negotiate •excruciate • aviate •abbreviate, alleviate, deviate •obviate • exuviate • inchoate •actuate • perpetuate • effectuate •habituate • fluctuate • punctuate •graduate • individuate • menstruate •accentuate, eventuate •evacuate •evaluate, valuate •superannuate • infatuate •attenuate, extenuate •insinuate • situate

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vi·ti·ate / ˈvishēˌāt/ • v. [tr.] formal spoil or impair the quality or efficiency of: development programs have been vitiated by the rise in population. ∎  destroy or impair the legal validity of. DERIVATIVES: vi·ti·a·tion / ˌvishēˈāshən/·ti·a·tor / -ˌātər/ n.

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vitiate render faulty or corrupt XVI; render of no effect XVII. f. pp. stem of L. vitiāre (after †vitiate pp. XV), f. vitium VICE1; see -ATE2,3.
So vitiation XVII. — L.

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To impair or make void; to destroy or annul, either completely or partially, the force and effect of an act or instrument.

Mutual mistake or fraud, for example, might vitiate a contract.