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salicylic acid

salicylic acid or 2-hydroxybenzoic acid, C6H4(OH)CO2H, a colorless, crystalline organic carboxylic acid that melts at 159°C; it is soluble in ethanol and ether but is only slightly soluble in water. It is prepared commercially by heating sodium phenolate (the sodium salt of phenol) with carbon dioxide under pressure to form sodium salicylate, which is treated with sulfuric acid to liberate salicylic acid. Salicylic acid and its derivatives are toxic when consumed in large amounts. Sodium salicylate is used to a small extent as a food preservative and as an antiseptic in mouthwashes and toothpastes. The major use of salicylic acid is in the preparation of its ester derivatives; since it contains both a hydroxyl (-OH) and a carboxyl (-CO2H) group, it can react with either an acid or an alcohol. The hydroxyl group reacts with acetic acid to form the acetate ester, acetylsalicylic acid (see aspirin). Several useful esters are formed by reaction of the carboxyl group with alcohols. The methyl ester, methyl salicylate (also called oil of wintergreen since it produces the fragrance of wintergreen), is formed with methanol; it is used in food flavorings and in liniments. The phenyl ester, phenyl salicylate, or salol, is formed with phenol; it is used in medicine as an antiseptic and antipyretic. This ester hydrolyzes, not in the acidic stomach, but in the alkaline intestines, releasing free salicylic acid. The menthyl ester, menthyl salicylate, which is used in suntan lotions, is formed with menthol.

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salicylic acid

sal·i·cyl·ic ac·id / ˌsaləˈsilik/ • n. Chem. a bitter compound, C6H4(OH)(COOH), present in certain plants. It is used as a fungicide and in the manufacture of aspirin and dyestuffs. DERIVATIVES: sa·lic·y·late / səˈlisəˌlāt; -lit/ n.

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salicylic acid

salicylic acid (sal-i-sil-ik) n. a drug that causes the skin to peel and destroys bacteria and fungi. It is applied to the skin, alone or in combination with other agents, to treat warts, corns, callus, acne, dandruff, psoriasis, and fungal infections. Trade names: Cuplex, Duofilm, Salactol, Verrugon, etc.

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salicylic acid

salicylic acid (C7H6O3) Colourless, crystalline solid, derivatives of which are used as analgesics (including aspirin, acetylsalicylic acid), antiseptics, dyes, and liniments. It occurs naturally in plants, including willow bark and oil of wintergreen.

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salicylic acid

salicylic acid (1-hydroxybenzoic acid) A naturally occurring carboxylic acid, HOC6H4COOH, found in certain plants. It is used in making aspirin and in the foodstuffs and dyestuffs industries.

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