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Tirano (tērä´nō), town (1991 pop. 8,919), Lombardy, N Italy, on the Adda River, in the Valtellina, near the Swiss border. It is an agricultural and silk market. Nearby is the Church of the Madonna di Tirano (1503), a popular place of pilgrimage. The Bernina railroad, the highest in the Alps, runs from Tirano to St. Moritz, Switzerland.