Sutherland, Earl Wilbur

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Earl Wilbur Sutherland, 1915–1974, American pharmacologist and physiologist, b. Burlingame, Kans., M.D., Washington Univ. Medical School, 1942. He was a professor at Washington Univ. (1945–53), at Western Reserve Univ. (now Case Western Reserve Univ., 1953–63), and at Vanderbilt Univ. (1963–74). Sutherland won the 1971 Nobel Prize in physiology or medicine for elucidating the behavior of hormones at the cellular level. He isolated cyclic adenosine monophosphate (cyclic AMP) and demonstrated its involvement in various metabolic processes. His work paved the way for later research on cell signaling and gene expression.