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Saffron is a herbal preparation harvested from the stigma of the Crocus sativus flower. It is dark orange and threadlike in appearance, with a spicy flavor and pungent odor. The plant is grown in India, Spain, France, Italy, the Middle East, and the eastern Mediterranean region.

General use

In addition to its culinary uses, saffron is prescribed as a herbal remedy to stimulate the digestive system, ease colic and stomach discomfort, and minimize gas . It is also used as an emmenagogue, to stimulate and promote menstrual flow in women.

Preliminary studies have shown that saffron may also be a useful tool in fighting cancer . According to a 1999 study, use of the herb slowed tumor growth and extended lifespan in female rats. A 2002 study done at Indiana University indicates that saffron may not only be effective in treating certain types of cancer, but significantly less likely to cause birth defects if given to pregnant women than all-trans-retinoic acid (ATRA), the compound most often given to treat these cancers. Saffron may thus be a preferable alternative to treating ATRA-sensitive cancers in women of childbearing age.

Additional human studies have indicated that saffron has powerful antioxidant properties; that is, it helps to protect living tissues from free radicals and other harmful effects of oxidation.

Two chemical components of saffron extract, crocetin and crocin, reportedly improved memory and learning skills in learning-impaired rats in a Japanese study published in early 2000. These properties indicate that saffron extract may be a useful treatment for neurodegenerative disorders and related memory impairment.


Saffron is harvested by drying the orange stigma of the Crocus sativus flower over fire. Over 200,000 crocus stigmas must be harvested to produce one pound of saffron. This volume makes the herb extremely expensive, and it is often cut with other substances of a similar color (e.g., marigold) to keep the price down.

Because saffron is frequently used as a spice to flavor a variety of dishes, particularly in Mediterranean recipes, it can often be purchased by mail order and at gourmet food stores as well as at health food stores. The herb is usually sold in either powdered form or in its original threadlike stigma form. Saffron can cost as much to $10.00 per gram.

For medicinal purposes, saffron can be taken by mouth in powder, tincture, or liquid form. To make a liquid saffron decoction, mix 610 stigmas or strands of saffron in one cup of cold water, bring the mixture to a boil, and then let it simmer. The saffron is then strained out of the decoction, which can be drunk either hot or cold. An average recommended dose of saffron decoction is 1/21 cup daily.

Saffron should be stored in an airtight container in a cool location away from bright light to maintain its potency. The herb can be frozen. Properly stored saffron can be used for up to two years. A good measure of the herb's freshness and potency is its odor. If the saffron does not have a noticeable pungent smell, it is probably past its peak.


Because saffron can stimulate uterine contractions, pregnant women should never take the herb for medicinal purposes.

Saffron should always be obtained from a reputable source that observes stringent quality control procedures and industry-accepted good manufacturing practices. Because

of its high cost, saffron is often found in adulterated form, so package labeling should be checked carefully for the type and quality of additional ingredients.

Botanical supplements are regulated by the FDA; however, they are currently not required to undergo any approval process before reaching the consumer market, and are classified as nutritional supplements rather than drugs. Legislation known as the Dietary Supplement Health and Education Act (DSHEA) was passed in 1994 in an effort to standardize the manufacture, labeling, composition, and safety of botanicals and supplements. In January 2000, the FDA's Center for Food Safety and Applied Nutrition (CFSAN) announced a ten-year plan for establishing and implementing these regulations by the year 2010.

Side effects

Although there are no known side effects or health hazards associated with recommended dosages of saffron preparations in healthy individuals, people with chronic medical conditions should consult with their healthcare professional before taking the herb. In addition, pregnant women should never take saffron, as the herb stimulates uterine contractions and may cause miscarriage.

Saffron can cause severe illness, kidney damage, central nervous system paralysis, and possible death at dosages of 12 g and higher. The symptoms of saffron poisoning include:

  • vomiting
  • uterine bleeding
  • intestinal cramping
  • bloody diarrhea
  • skin hemorrhaging
  • dizziness
  • stupor
  • paralysis

If any of these symptoms occur, the user discontinue the use of saffron immediately and seek emergency medical assistance.


As of 2002, there are no reported negative interactions between saffron and other medications and herbs, although certain drugs with the same therapeutic properties as saffron may enhance the effect of the herb.



Hoffman, David. The Complete Illustrated Herbal. New York: Barnes & Noble Books, 1999.

Medical Economics Corporation. The PDR for Herbal Medicines. Montvale, NJ: Medical Economics Corporation, 1998.


Martin, G., E. Goh, and A. W. Neff. "Evaluation of the Developmental Toxicity of Crocetin on Xenopus." Food and Chemical Toxicology 40 (July 2002): 959-964.


Office of Dietary Supplements. National Institutes of Health. Building 31, Room 1B25. 31 Center Drive, MSC 2086. Bethesda, MD 20892-2086. (301) 435-2920. Fax: (301) 480-1845.

United States Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition. 5100 Paint Branch Parkway, College Park, MD 20740. (888) SAFEFOOD. <>.

Paula Ford-Martin

Rebecca J. Frey, PhD

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SAFFRON (Heb. כַּרְכֹּם, karkom), the Crocus sativus; an aromatic golden dye was extracted from the stigmas of its golden blossoms. It was also dried and used for flavoring foods. In the Bible karkom is mentioned once among the various spices that grew in the imaginary spice garden to which the charms of the beloved are compared (Song 4:14). Most of them are enumerated in an early baraita as ingredients of the incense used in the Temple (Ker. 6a; v. Pittum ha-Ketoret). Since both passages refer to tropical spices brought from distant lands, Immanuel Loew was of the opinion that the karkom is a tropical incense plant, the Curcuma longa, called by the ancients "Indian saffron," Crocus indicus. This belongs to the family of Zingiberaceae from whose rhizome a golden yellow material called Curcumin is extracted and used for dyeing and flavoring food, as well as for dyeing clothes. This identification is doubtful, however, because the substance is not especially aromatic, nor is there any reason to doubt the traditional explanation that biblical karkom is indeed identical with saffron (Sanskrit kurkuma, Gr. and Lat. krokos). It is a tuber which apparently originated in the mountains of the Caspian Sea region. Its name in Aramaic and Arabic is zafrana, from which the word saffron is derived. During the mishnaic and talmudic period saffron was widely used in Ereẓ Israel and Babylon. It was planted in fields, and a "field full of saffron" was considered very precious. According to tradition, Joshua the son of Nun had already made regulations with regard to this plant (bk 81a). The verb nitkarkem (i.e., "turned yellow," pale) derives from the yellow color of the karkom (Gen. R. 99:9 et al.). In the Talmud, Abbaye describes the structure of the stigma from which the saffron was extracted (Nid. 20a). In medieval times saffron was a valuable commodity and Jews traded extensively in it. Since some adulterated saffron by adding fibers of horse meat to it, Solomon b. Abraham *Adret of Barcelona in the 13th century forbade its use in food. The yellow *badge the Jews were compelled to wear – according to the first papal decree instituting it – had to be dyed with saffron (see Singermann in bibl.). The importance of saffron has diminished, although Oriental Jews occasionally use it to color and flavor their food. It is hardly grown at all in Israel. Seven species of crocus, some with very beautiful flowers, grow wild in Israel.


F. Singermann, Ueber Juden-Abzeichen (1915); Loew, Flora, 2 (1924), 7–25; H.N. and A.L. Moldenke, Plants of the Bible (1952), index; J. Feliks, Olam ha-Ẓome'aḥ ha-Mikra'i (19682), 249–51.

[Jehuda Feliks]

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saf·fron / ˈsafrən/ • n. 1. an orange-yellow flavoring, food coloring, and dye made from the dried stigmas of a crocus: [as adj.] saffron buns. ∎  the orange-yellow color of this. 2. (also saffron crocus) an autumn-flowering crocus (Crocus sativus) with reddish-purple flowers, native to warmer regions of Eurasia. Enormous numbers of flowers are required to produce a small quantity of the large red stigmas used for the spice. DERIVATIVES: saf·fron·y adj.

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saffronAran, Arran, baron, barren, Darren, Karen, Sharon, yarran •Biafran, saffron •plastron • Saharan • Sumatran •heron, perron •rhododendron • chevron •Aaron, Charon, Dáil Eireann •apron •matron, patron •Libran •decahedron, dodecahedron, octahedron, polyhedron, tetrahedron •children • citron • grandchildren •stepchildren • godchildren •schoolchildren •Byron, Chiron, environ, Myron, siren •sporran, warren •squadron • Cochran •Andorran, Doran, Lauren, loran •cauldron •Kieran, Madeiran, schlieren •Honduran, Van Buren •Aldebaran • Auberon • Acheron •Cameron, Decameron •cateran, Lateran •veteran •dipteran, hemipteran •lepidopteran • Lutheran

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saffron (autumn crocus) Perennial crocus, native to Asia Minor and cultivated in Europe. It has purple or white flowers. The golden, dried stigmas of the plant are used as a flavouring or dye. Family Iridaceae; species Crocus sativus.

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saffron Orange powder from the stigmata of the saffron crocus, Crocus sativus; 1 g requires the stigmata of 1500 flowers and yields about 50 mg of extract. Used as natural food colour and spice. Very soluble in water.

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saffron Colouring and flavouring obtained from Crocus sativus and the dried stigmas that produce them. See CROCUS.

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saffron (orange-red product of) the plant Crocus sativus XIII; autumn crocus XV. ME. saffran, safron — (O)F. safran — Arab. za'farān.