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ciprofloxacin (sip-roh-floks-ă-sin) n. a broad-spectrum quinolone antibiotic that can be given orally or by intravenous infusion and is particularly useful against Gram-negative bacteria, such as Pseudomonas, that are resistant to all other oral antibiotics. It is also applied as eye drops or ointment to treat eye infections and corneal ulcers. Trade names:. Ciloxan,. Ciproxin.