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Quaternary Structure

Quaternary Structure


Many proteins are made up of a single, continuous polypeptide chain and are thus called monomeric. Other proteins are composed of two or more polypeptide chains called subunits. The quaternary structure describes the arrangement and position of each of the subunits in a multiunit protein. The stabilizing forces that hold the polypeptide subunits together are the same forces that are responsible for tertiary structure stabilization. A major force stabilizing the quaternary structure is the hydrophobic interaction among nonpolar side chains at the contact regions of the subunits. Additional stabilizing forces include interactions between side chains of the subunits, including electrostatic interactions between ionic groups of opposite charge:

hydrogen bonds between polar groups; and disulfide bonds . An example of a protein with quaternary structure is hemoglobin. Hemoglobin, an oxygen transport protein, is a tetrameric (four unit) protein consisting of two α and two β subunits .

see also Primary Structure; Proteins; Secondary Structure; Tertiary Structure.

Elizabeth S. Roberts-Kirchhoff

Bibliography

Perutz, Max F. (1978). "Hemoglobin Structure and Respiratory Transport." Scientific American 239: 9293.

Internet Resources

Martz, Eric. "Hemoglobin." Martz Molecular Visualization and Immunology Sites. Available from <http://www.umass.edu/>.

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quaternary structure

quaternary structure The structure of a protein that results from the interaction of two or more individual polypeptides to give larger functional molecules. Compare PRIMARY STRUCTURE; SECONDARY STRUCTURE; TERTIARY STRUCTURE.

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quaternary structure

quaternary structure The structure of a protein that results from the interaction of two or more individual polypeptides to give larger functional molecules.Compare PRIMARY STRUCTURE and TERTIARY STRUCTURE.

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quaternary structure

quaternary structure See protein.

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