cell fusion (somatic cell hybridization) The technique of combining two cells from different tissues or species in a cell culture. The cells are fused (see chemical fusogen) and coalesce but their nuclei generally remain separate. However, during cell division a single spindle is formed so that each daughter cell has a single nucleus containing sets of chromosomes from each parental line. Subsequent division of the hybrid cells often results in the loss of chromosomes (and therefore genes), so that absence of a gene product in the culture can be related to the loss of a particular chromosome. Thus the technique is used to determine the control of characteristics exerted by specific chromosomes. Hybrid cells (see hybridoma) resulting from cell fusion have also been used to produce monoclonal antibodies.
cell fusion The experimental fusion of nuclei and cytoplasm from different somatic cells to form a single hybrid cell. Cells used for fusion often come from tissue cultures derived from different species: fusion is facilitated by the modification of the surface of cells by adsorption of certain viruses (e.g. Sendai virus).
cell fusion The experimental fusion of nuclei and cytoplasm from different somatic cells to form a single hybrid cell. Cells used for fusion often come from tissue cultures derived from different species; fusion is facilitated by the modification of the surface of cells by adsorption of certain viruses (e.g. Sendai virus).
More From encyclopedia.com
Schwann Cell , Schwann cell (neurilemma cell) A cell that forms the myelin sheath of a nerve fibre. Each cell is responsible for a single length of the fibre (calle… Adherens Junction , adherens junction A cell junction that is commonly observed in epithelial (see EPITHELIUM) cells (e.g. those lining the intestine and those in cardia… T Cell , T cell T cell (T lymphocyte) Any of a population of lymphocytes that are the principal agents of cell-mediated immunity. T cells are derived from the… Cell Culture , Cell culture describes the laboratory growth of cells derived from plants or animals. To put cells into culture, the tissue of interest is exposed to… Caulobacter , Caulobacter crescentus is a Gram-negative rod-like bacterium that inhabits fresh water. It is noteworthy principally because of the unusual nature of… Cytology , Cytology is the branch of biology that studies cells, the building blocks of life. The name for this science is translated from kytos, the Greek term…
About this article
All Sources -
Updated About encyclopedia.com content Print Topic
You Might Also Like