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SSRI (selective serotonin reuptake inhibitor) n. any one of a group of antidepressant drugs that exert their action by blocking the reabsorption of the neurotransmitter serotonin by the nerve endings in the brain. Their effect is to prolong the action of serotonin in the brain. The group includes citolapram, fluoxetine, fluvoxamine, paroxetine, and sertraline. The most common side-effects are nausea, indigestion, abdominal pain, and other gastrointestinal upsets.