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adrenoceptor

adrenoceptor (adrenoreceptor; adrenergic receptor) Any cell receptor that binds and is activated by the catecholamines adrenaline or noradrenaline. Adrenoceptors are therefore crucial in mediating the effects of catecholamines as neurotransmitters or hormones. There are two principal types of adrenoceptor, alpha (α) and beta (β), and various subtypes of each, with differing sensitivities to the catecholamines and to certain drugs. The alpha adrenoceptors fall into two main subtypes: α1-adrenoceptors, which mediate the contraction of smooth muscle and hence, for example, cause constriction of blood vessels due to contraction of their muscular walls; and α2-adrenoceptors, which occur, for example, in presynaptic neurons at certain nerve synapses, where they inhibit release of noradrenaline from the neuron. The beta adrenoceptors also have two main subtypes: β1-adrenoceptors, which stimulate cardiac muscle causing a faster and stronger heartbeat; and β2-adrenoceptors, which mediate relaxation of smooth muscle in blood vessels, bronchi, the uterus, bladder, and other organs. Activation of β2-adrenoceptors thus causes widening of the airways (bronchodilation) and blood vessels (vasodilation). See also beta blocker

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adrenoceptor

adrenoceptor (ă-dree-noh-sep-ter) n. see adrenergic (receptor).

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