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hoo·doo / ˈhoōˌdoō/ • n. 1. voodoo; witchcraft. ∎  a run of bad luck associated with a person or activity: when is this hoodoo going to end? ∎  a person or thing that brings or causes bad luck.2. a column or pinnacle of weathered rock: a towering sandstone hoodoo.• v. (-doos, -dooed) [tr.] bewitch: she's hoodooed you. ∎  bring bad luck to: a fine player, but repeatedly hoodooed.