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streptokinase (strep-toh-ky-nayz) n. an enzyme produced by some haemolytic bacteria of the genus Streptococcus that is capable of liquefying blood clots (see fibrinolytic). It is injected to treat blockage of blood vessels and is also used in combination with streptodornase as a topical preparation (Varidase Topical) to remove slough and blood clot and thus promote healing of ulcers. Trade name: Streptase.