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Helicobacter (hel-i-koh-bak-ter) n. a genus of spiral and flagellated Gram-negative bacteria. H. pylori (formerly Campylobacter pylori) a species that occurs in the stomach and causes progressive gastritis. It is nearly always present in duodenal ulceration and usually in gastric ulceration, and has been implicated in lymphomas of the stomach. It can be eradicated using various combinations of antibiotics and antisecretory drugs.