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colestyramine (cholestyramine) (koli-sty-ră-meen) n. a drug that binds bile acids (see bile-acid sequestrant). It is administered by mouth to relieve conditions due to irritant effects of bile acids (such as the itching that occurs in obstructive jaundice), to treat diarrhoea, and to lower blood levels of cholesterol and other fats. Trade names:. Questran,. Questran Light.