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co-phenotrope (koh-fen-ŏ-trohp) n. a drug administered by mouth in the treatment of diarrhoea. It consists of a mixture of diphenoxylate hydrochloride (an opioid that reduces peristalsis) and atropine (which relaxes the smooth muscle of the gut) in a ratio of 100 to 1. Trade name: Lomotil.