glucuronic acid A compound, OC6H9O6, derived from the oxidation of glucose. It is an important constituent of gums and mucilages. Glucuronic acid can combine with hydroxyl (–OH), carboxyl (–COOH), or amino (–NH2) groups to form a glucuronide. The addition of a glucuronide group to a molecule (glucuronidation) generally increases the solubility of a compound; hence glucuronidation plays an important role in the excretion of foreign substances (see phase II metabolism).
glucuronic acid (gloo-kewr-on-ik) n. a sugar acid derived from glucose. Glucuronic acid is an important constituent of chondroitin sulphate (found in cartilage) and hyaluronic acid (found in synovial fluid).
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