homeobox A nucleotide sequence containing about 180 base pairs, which are identical or very similar in many eukaryotic organisms, that encodes a series of amino acids known as a homeodomain. Present in many eukaryotic regulatory proteins, this domain is an important region involved in the binding of regulatory proteins to the DNA molecule. A homeobox was first identified in the homeotic genes of Drosophila and has since been found in the homeotic genes of many animals (including humans) and in plants.
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