Skip to main content
Select Source:

Amsacrine

Amsacrine

Definition

Amsacrine is an antitumor agent used to treat adult acute leukemia . It is no longer commercially available in the United States, although it is available in Canada.

Purpose

Amsacrine is an investigational drug used to treat refractory acute lymphocytic and nonlymphocytic leukemias, Hodgkin's disease , and non-Hodgkin's lymphomas . It may also have some activity against head and neck cancers .

Description

Amsacrine inhibits the synthesis of DNA. It also inhibits the enzyme responsible for cutting the strands of DNA, and untwists DNA so that replication of DNA can't occur.

Recommended dosage

The dose for amsacrine may be different depending on the protocol used by the physician. The drug is given through the vein as a 30-to 90-minute infusion or as a 24-hour continuous infusion. Example doses for adults are: 60 to 160 mg per square meter of body surface area every three to four weeks, or 40 to 120 mg per square meter of body surface area for five to seven days every three to four weeks. The dose for children is 120 to 150 mg per square meter of body surface area per day for five days. The dose of amsacrine is usually decreased in patients with decreased kidney or liver function.

Precautions

Amsacrine is usually given with caution to patients with underlying heart disease, severe kidney or liver disease, or to patients who have received high doses of anthracycline chemotherapy drugs, such as doxorubicin .

Although the effects of amsacrine treatment on children are currently unknown, caution is still indicated. Women of childbearing age should take precautions to prevent pregnancy while on this drug. Women should not breastfeed while taking this medication.

Side effects

Toxicity to the heart is a common side effect of amsacrine, and patients receiving this drug are usually very closely monitored by their physician. Other common side effects of amsacrine include nausea and vomiting , diarrhea , ulcerations of the mouth and the gastrointestinal tract, decreased white blood cells and platelets, and decreased liver function. Patients may notice orange-red discoloration of the urine, but should not be alarmed as this is normal. The urine will clear again once all the drugs have been eliminated from the body. Other common side effects include headache, dizziness, confusion, seizures, abnormal touch sensation such as burning and prickling, and blurred vision. As with any side effects that occur while taking any medications, patients should notify their doctor or nurse immediately.

Interactions

To prevent any drug interactions, patients should consult their physician, nurse, or pharmacist prior to taking any over-the-counter medications, herbal medications, or new medications. Many physicians recommend bringing the containers with the names of the drugs to an appointment.

Michael V. Zuck, Ph.D.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"Amsacrine." Gale Encyclopedia of Cancer. . Encyclopedia.com. 13 Nov. 2018 <https://www.encyclopedia.com>.

"Amsacrine." Gale Encyclopedia of Cancer. . Encyclopedia.com. (November 13, 2018). https://www.encyclopedia.com/medicine/encyclopedias-almanacs-transcripts-and-maps/amsacrine

"Amsacrine." Gale Encyclopedia of Cancer. . Retrieved November 13, 2018 from Encyclopedia.com: https://www.encyclopedia.com/medicine/encyclopedias-almanacs-transcripts-and-maps/amsacrine

Learn more about citation styles

Citation styles

Encyclopedia.com gives you the ability to cite reference entries and articles according to common styles from the Modern Language Association (MLA), The Chicago Manual of Style, and the American Psychological Association (APA).

Within the “Cite this article” tool, pick a style to see how all available information looks when formatted according to that style. Then, copy and paste the text into your bibliography or works cited list.

Because each style has its own formatting nuances that evolve over time and not all information is available for every reference entry or article, Encyclopedia.com cannot guarantee each citation it generates. Therefore, it’s best to use Encyclopedia.com citations as a starting point before checking the style against your school or publication’s requirements and the most-recent information available at these sites:

Modern Language Association

http://www.mla.org/style

The Chicago Manual of Style

http://www.chicagomanualofstyle.org/tools_citationguide.html

American Psychological Association

http://apastyle.apa.org/

Notes:
  • Most online reference entries and articles do not have page numbers. Therefore, that information is unavailable for most Encyclopedia.com content. However, the date of retrieval is often important. Refer to each style’s convention regarding the best way to format page numbers and retrieval dates.
  • In addition to the MLA, Chicago, and APA styles, your school, university, publication, or institution may have its own requirements for citations. Therefore, be sure to refer to those guidelines when editing your bibliography or works cited list.

amsacrine

amsacrine (am-să-kreen) n. a cytotoxic drug administered by intravenous injection to treat acute myeloid leukaemia. Trade name: Amsidine.

Cite this article
Pick a style below, and copy the text for your bibliography.

  • MLA
  • Chicago
  • APA

"amsacrine." A Dictionary of Nursing. . Encyclopedia.com. 13 Nov. 2018 <https://www.encyclopedia.com>.

"amsacrine." A Dictionary of Nursing. . Encyclopedia.com. (November 13, 2018). https://www.encyclopedia.com/caregiving/dictionaries-thesauruses-pictures-and-press-releases/amsacrine

"amsacrine." A Dictionary of Nursing. . Retrieved November 13, 2018 from Encyclopedia.com: https://www.encyclopedia.com/caregiving/dictionaries-thesauruses-pictures-and-press-releases/amsacrine

Learn more about citation styles

Citation styles

Encyclopedia.com gives you the ability to cite reference entries and articles according to common styles from the Modern Language Association (MLA), The Chicago Manual of Style, and the American Psychological Association (APA).

Within the “Cite this article” tool, pick a style to see how all available information looks when formatted according to that style. Then, copy and paste the text into your bibliography or works cited list.

Because each style has its own formatting nuances that evolve over time and not all information is available for every reference entry or article, Encyclopedia.com cannot guarantee each citation it generates. Therefore, it’s best to use Encyclopedia.com citations as a starting point before checking the style against your school or publication’s requirements and the most-recent information available at these sites:

Modern Language Association

http://www.mla.org/style

The Chicago Manual of Style

http://www.chicagomanualofstyle.org/tools_citationguide.html

American Psychological Association

http://apastyle.apa.org/

Notes:
  • Most online reference entries and articles do not have page numbers. Therefore, that information is unavailable for most Encyclopedia.com content. However, the date of retrieval is often important. Refer to each style’s convention regarding the best way to format page numbers and retrieval dates.
  • In addition to the MLA, Chicago, and APA styles, your school, university, publication, or institution may have its own requirements for citations. Therefore, be sure to refer to those guidelines when editing your bibliography or works cited list.