Thyroglobulin

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thyroglobulin The protein in the thyroid gland which is the precursor for the synthesis of the thyroid hormones. The thyroid‐stimulating hormone of the pituitary gland stimulates hydrolysis of thyroglobulin and secretion of the hormones into the bloodstream.

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thyroglobulin An iodinated protein of the gelatinous colloid of the thyroid gland which is chiefly responsible for the storage of iodine in that gland and from which the hormones thyroxine and triiodothyronine are formed.

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thyroglobulin (TGB) A glycoprotein, made in the thyroid gland, that consists of about 5000 amino acids, some of which are tyrosine residues. TGB is the precursor of the thyroid hormones, thyroxine and triiodothyronine. Iodine binds to the tyrosine residues in thyroglobulin, which is then hydrolysed into iodotyrosines that combine to form triiodothyronine (T3) or thyroxine (tetraiodothyronine or T4).

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thyroglobulin (th'y-roh-glob-yoo-lin) n. a protein in the thyroid gland from which the thyroid hormones are synthesized.