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oc·clude / əˈkloōd/ • v. formal or technical 1. [tr.] stop, close up, or obstruct (an opening, orifice, or passage): thick makeup can occlude the pores. ∎  shut (something) in: they were occluding the waterfront with a wall of buildings. ∎  technical cover (an eye) to prevent its use: it is placed at eye level with one eye occluded. ∎  Chem. (of a solid) absorb and retain (a gas or impurity). 2. [intr.] (of a tooth) close on or come into contact with another tooth in the opposite jaw.