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polyposis (poli-poh-sis) n. a condition in which numerous polyps form in an organ or tissue. familial adenomatous p. (p. coli) a hereditary disease in which multiple adenomas develop in the gastrointestinal tract, usually the colon or rectum, at an early age. As these polyps almost invariably become malignant, patients are usually advised to undergo total removal of the affected bowel. See also Peutz-Jeghers syndrome. Compare pseudopolyposis.