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infliximab (in-fliks-i-mab) n. a monoclonal antibody that inhibits the activity of TNF-α (see tumour necrosis factor) and is used to treat severe Crohn's disease and rheumatoid arthritis that have failed to respond to treatment with corticosteroids or immunosuppressants and antirheumatic drugs, respectively. It is administered by infusion. Trade name: Remicade.