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Coxsackie virus (kok-sak-i) n. one of a group of RNA-containing viruses that are able to multiply in the gastrointestinal tract (see enterovirus). Type A viruses generally cause less severe diseases, although some cause meningitis and severe throat infections. Type B viruses cause inflammation or degeneration of brain or heart tissue and they can also attack the muscles of the chest wall, the bronchi, pancreas, thyroid, and conjunctiva. See also Bornholm disease, hand, foot, and mouth disease.