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hydroxyproline Amino acid mainly in connective tissue proteins (collagen and elastin); incorporated into the protein as proline and then hydroxylated in a vitamin‐C‐dependent reaction. Peptides of hydroxyproline are excreted in the urine and the output is increased when collagen turnover is high, as in rapid growth or resorption of tissue.

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hydroxyproline (hy-droks-i-proh-leen) n. a compound, similar in structure to the amino acids, found only in collagen.