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Merck & Co., Inc.

Merck & Co., Inc.

One Merck Drive
P.O. Box 100
White House Station, New Jersey 08889-0100
U.S.A.
Telephone: (908) 423-1000
Toll Free: (800) 613-2104
Fax: (908) 423-1043
Web site: http://www.merck.com

Public Company
Incorporated: 1927
Employees: 62,300
Sales: $32.71 billion (1999)
Stock Exchanges: New York Boston Cincinnati
Philadelphia Pacific
Ticker Symbol: MRK
NAIC: 325412 Pharmaceutical Preparation Manufacturing; 325199 All Other Basic Organic Chemical Manufacturing; 325411 Medicinal and Botanical Manufacturing; 325413 In-Vitro Diagnostic Substance Manufacturing; 325414 Biological Product (except Diagnostic) Manufacturing; 422210 Drugs and Druggists Sundries Wholesalers; 454110 Electronic Shopping and Mail-Order Houses; 541710 Research and Development in the Physical, Engineering, and Life Sciences

Merck & Co., Inc. is one of the largest pharmaceutical companies in the world. Among the companys most important prescription drugs are Vioxx, a painkiller used to treat arthritis; Zocor and Mevacor, used to modify cholesterol levels; Cozaar, Prinivil, and Vasotec, hypertension medications; Fosamax, for the treatment and prevention of osteoporosis; Pepcid, an ulcer medication; Primaxin and Noroxin, antibiotics; Crixivan, a protease inhibitor used in the treatment of HIV; Singulair, an asthma treatment; Cosopt, Timoptic, and Trusopt, all used to treat glaucoma; Propecia, a hair loss remedy; and several vaccines, including M-M-R II, chicken pox vaccine Varivax, and hepatitis B vaccine Recombivax HB. Merck also develops, manufactures, and markets pharmaceuticals through a number of joint ventures, including: a partnership with Johnson & Johnson that concentrates on designing and commercializing over-the-counter versions of prescription medications, such as Pepcid AC; a venture with Aventis A.G. focusing on the European vaccine market; and another partnership with Aventis, this one concentrating on animal health and poultry genetics. Nearly half of the companys revenues are generated by Merck-Medco Managed Care, a pharmacy benefit management subsidiary principally involved in selling prescription drugs through managed prescription drug programs. Merck spends more than $2 billion each year on pharmaceutical research and development. About 40 percent of the companys human health product sales are generated outside the United States.

German Origins

Mercks beginnings can be traced back to Friedrich Jacob Mercks 1668 purchase of an apothecary in Darmstadt, Germany, calledAt the Sign of the Angel.Located next to a castle moat, this store remained in the Merck family for generations.

The pharmacy was transformed by Heinrich Emmanuel Merck into a drug manufactory in 1827. His first products were morphine, codeine, and cocaine. By the time he died in 1855, products made by his company, known as E. Merck AG, were used worldwide. In 1887 E. Merck sent a representative, Theodore Weicker, to the United States to set up a sales office. Weicker (who would go on to own drug powerhouse Bristol-Myers Squibb) was joined by George Merck, the 24-year-old grandson of Heinrich Emmanuel Merck in 1891. In 1899, the younger Merck and Weicker acquired a 150-acre plant site in Rahway, New Jersey, and started production in 1903. Weicker left the firm the following year.

The manufacture of drugs and chemicals at this site began in 1903. This same location housed the corporate headquarters of Merck & Co. and four of its divisions, as well as research laboratories and chemical production facilities, into the 1990s. Once known asMerck Woods,the land surrounding the original plant was used to hunt wild game and corral domestic animals. In fact, George Merck kept a flock of 15 to 20 sheep on the grounds to test the effectiveness of an animal disinfectant. The sheep became a permanent part of the Rahway landscape.

The year 1899 also marked the first year the Merck Manual of Diagnosis and Therapy was published. In 1983, the manual entered its 14th edition. A New York Times review rated it the most widely used medical text in the world.

In 1917, upon the entrance of the United States into World War I, George Merck, fearing anti-German sentiment, turned over a sizable portion of Merck stock to the Alien Property Custodian of the United States. This portion represented the company interest held by E. Merck AG, thereby ending Merck & Co.s connection to its German parent. At the end of the war, Merck was rewarded for his patriotic leadership; the Alien Property Custodian sold Merck shares, worth $3 million, to the public. George Merck retained control of the corporation, and by 1919 the company was once again entirely public-owned.

1920s Through 1950s: Growth Through Mergers and R&D

By 1926, the year George Merck died, his son George W. Merck had been acting president for more than a year. The first major event of the younger Mercks tenurewhich would last 25 yearswas the 1927 merger with Philadelphia-based Powers-Weightman-Rosengarten, a pharmaceutical firm best known for antimalarial quinine. Following the merger, Merck incorporated his company as Merck & Co., Inc. The merger enabled Merck & Co. to increase its sales from $6 million in 1925 to more than $13 million in 1929. With the resultant expansion in capital, Merck initiated and directed the Merck legacy for pioneering research and development. In 1933, he established a large laboratory and recruited prominent chemists and biologists to produce new pharmaceutical products. Their efforts had far-reaching effects. En route to researching cures for pernicious anemia, Merck scientists discovered vitamin B12. Its sales, both as a therapeutic drug and as a constituent of animal feed, were massive.

The 1940s continued to be a decade of discoveries in drug research, especially in the field of steroid chemistry. In the early 1940s, a Merck chemist synthesized cortisone from ox bile, which led to the discovery of cortisones anti-inflammation properties. In 1943, streptomycin, a revolutionary antibiotic used for tuberculosis and other infections, was isolated by a Merck scientist.

Despite the pioneering efforts and research success under George W. Mercks leadership, the company struggled during the postwar years. There were no promising new drugs to speak of, and there was intense competition from foreign companies underselling Merck products, as well as from former domestic consumers beginning to manufacture their own drugs. Merck found itself in a precarious financial position.

A solution was found in 1953 when Merck merged with Sharp & Dohme, Incorporated, a drug company with a similar history and reputation. Sharp and Dohme began as an apothecary shop in 1845 in Baltimore, Maryland. Its success in the research and development of such important products as sulfa drugs, vaccines, and blood plasma products matched the successes of Merck. The merger, however, was more than the combination of two industry leaders. It provided Merck with a new distribution network and marketing facilities to secure major customers. For the first time, Merck could market and sell drugs under its own name.

At the time of George W. Mercks death in 1957, company sales had surpassed $100 million annually. Although Albert W. Merck, a direct descendant of Friedrich Jacob Merck, continued to sit on the board of directors into the 1980s, the office of chief executive was never again held by a Merck family member.

1960s Through Mid-1980s: Diversifying, Reemphasizing Research,Surviving Various Difficulties

Henry W. Gadsen became CEO in 1965 and, as was fashionable at the time, initiated a program of diversification. Among the businesses acquired in the late 1960s and early 1970s were Calgon Corporation, a supplier of water treatment chemicals and services; Kelco, a maker of specialty chemicals; and Baltimore Aircoil, a maker of refrigeration and industrial cooling equipment. Many of these businesses were quickly divested after it was discovered that profits were hard to come by, but Calgon and Kelco remained part of Merck into the early 1990s. Under Gadsens emphasis on diversification, Mercks pharmaceutical operations suffered.

In 1976, John J. Honran succeeded the 11-year reign of Gadsen. Honran was a quiet, unassuming man who had entered Merck as a legal counselor and then became the corporate director of public relations. But Honrans unobtrusive manner belied an aggressive management style. With pragmatic determination Honran not only continued the Merck tradition for innovation in drug research, but also improved a poor performance record on new product introduction to the market.

This problem was most apparent in the marketing of Aldomet, an antihypertensive agent. Once the research was completed, Merck planned to exploit the discovery by introducing an improved beta-blocker called Blocadren. Yet Merck was beaten to the market by its competitors. Furthermore, because the 17-year patent protection on a new drug discovery was about to expire, Aldomet was threatened by generic manufacturers. This failure to beat its competitors to the market is said to have cost the company $200 million in future sales. A similar sequence of events occurred with Indocin and Clinoril, two anti-inflammation drugs for arthritis.

Company Perspectives:

The mission of Merck is to provide society with superior products and services innovations and solutions that improve the quality of life and satisfy customer needs to provide employees with meaningful work and advancement opportunities and investors with a superior rate of return.

Under Honrans regime, the company introduced a hepatitis vaccine, a treatment for glaucoma called Timoptic, and Ivomac, an antiparasitic for animals. In addition, while Honran remained strongly committed to financing a highly productive research organization, Merck began making improvements on research already performed by competitors. In 1979, for example, Merck began to market Enalapril, a high-blood-pressure inhibitor, similar to the drug Capoten, which was manufactured by Squibb. Sales for Enalapril reached $550 million in 1986. Honran also embarked on a more aggressive program for licensing foreign products. In 1982 Merck purchased rights to sell products from Swedish firm Astra AB in the United States; a similar arrangement was reached with Shionogi of Japan. Two years later the Merck-Astra agreement was transformed into a joint venture, Astra Merck Inc.

Honrans strategy proved very effective. Between 1981 and 1985, the company experienced a nine percent annual growth rate, and in 1985 the Wall Street Transcript awarded Honran the gold award for excellence in the ethical drug industry. He was commended for the companys advanced marketing techniques and its increased production. At the time of the award, projections indicated a company growth rate for the next five years of double the present rate.

In 1984, Honran claimed Merck had become the largest U.S.-based manufacturer of drugs in the three largest marketsthe United States, Japan, and Europe. He attributed this success to three factors: a productive research organization; manufacturing capability that allowed for cost-efficient, high-quality production; and an excellent marketing organization. The following year, Honran resigned as CEO. In 1986, his successor, Dr. P. Roy Vagelos, a biochemist and the companys former head of research, also was awarded the ethical drug industrys gold award.

Although Mercks public image was generally good, it had its share of controversy. In 1974, a $35 million lawsuit was filed against Merck and 28 other drug manufacturers and distributors of diethylstilbestrol (DES). This drug, prescribed to pregnant women in the late 1940s and up until the early 1960s, ostensibly prevented miscarriages. The 16 original plaintiffs claimed that they developed vaginal cancer and other related difficulties because their mothers had taken the drug. Furthermore, the suit charged that DES was derived from Stilbene, a known carcinogen, and that no reasonable basis existed for claiming the drugs were effective in preventing miscarriages. (A year before the suit, the Federal Drug Administration, or FDA, banned the use of DES hormones as growth stimulants for cattle because tests revealed cancer-causing residues of the substance in some of the animals livers. The FDA, however, did not conduct public hearings on this issue; consequently, a federal court overturned the ban.)

Under the plaintiffs directive, the court asked the defendants to notify other possible victims and to establish early detection and treatment centers. More than 350 plaintiffs subsequently sought damages totaling some $350 billion.

Key Dates:

1668:
Friedrich Jacob Merck purchases an apothecary in Darmstadt, Germany.
1827:
Heinrich Emmanuel Merck transforms the pharmacy into a drug manufactory.
1887:
The German firm, E. Merck AG, sets up a sales office in the United States.
1891:
George Merck, grandson of Heinrich Merck, joins the U.S. branch, known as Merck & Company.
1899:
The Merck Manual of Diagnosis and Therapy is first published.
1903:
U.S. production begins at a site in Rahway, New Jersey.
1917:
Entrance of United States into World War I leads to severing of relationship between Merck & Co. and E. Merck AG.
1925:
George W. Merck takes over as president, succeeding his father.
1927:
Company merges with Powers-Weightman-Rosen-garten and is incorporated as Merck & Co., Inc.
1940s:
Mercks laboratories make a series of discoveries: vitamin B12, cortisone, streptomycin.
1953:
Company merges with Sharp & Dohme, Incorporated.
1965:
Henry W. Gadsen is named CEO and launches an ill-advised diversification program.
1976:
John J. Honran succeeds Gadsen and reemphasizes drug research.
1979:
Company begins marketing Enalapril, a high-blood-pressure inhibitor whose annual sales eventually reach $550 million.
1982:
Merck enters into a partnership with Astra AB to sell that companys products in the United States.
1985:
Dr. P. Roy Vagelos takes over as CEO; Vasotec, a treatment for congestive heart failure, is introduced.
1988:
Vasotec becomes Mercks first billion-dollar-a-year drug.
1989:
Over-the-counter medication joint venture is created with Johnson & Johnson.
1992:
Zocor, a cholesterol-fighter, is introduced and eventually becomes a blockbuster.
1993:
Medco Containment Services Inc., a drug distributor, is acquired for $6.6 billion.
1994:
Raymond V. Gilmartin is named chairman and CEO, becoming the first outsider so named.
1995:
Company divests its specialty chemicals businesses.
1999:
Astra pays Merck $1.8 billion stemming from a joint venture between the companies and from Astras merger with Zeneca; arthritis medication Vioxx makes its debut.

Merck was not beleaguered by the DES lawsuit only. In 1975, the companys name was added to a growing list of U.S. companies involved in illegal payments abroad. The payoffs, issued to increase sales in certain African and Middle Eastern countries, came to the attention of Merck executives through the investigation of the Securities and Exchange Commission. While sales amounted to $40.4 million for that year in those areas of the foreign market, the report uncovered a total of $140,000 in bribes. Once the SEC revealed its report, Merck initiated an internal investigation and took immediate steps to prevent future illegal payments.

Later, Merck found itself beset with new difficulties. In its attempt to win hegemony in Japan, the second largest pharmaceutical market in the world, Merck purchased more than 50 percent of the Banyu Pharmaceutical Company of Tokyo. Partners since 1954 under a joint business venture called Nippon Merck-Banyu (NMB), the companies used Japanese detail men (or pharmaceutical sales representatives) to promote Merck products.

When NMB proved inefficient, however, Merck bought out its partner for $315.5 millionmore than 30 times Banyus annual earnings. The acquisition was made in 1982, and Merck was still in the process of bringing Banyu into line with its more aggressive and imaginative management style in the early 1990s.

Problems in labor relations surfaced during the spring of 1985 when Merck locked out 730 union employees at the Rahway plant after failing to agree to a new contract. For three months prior to the expiration of three union contracts, involving 4,000 employees, both sides negotiated a new settlement. When talks stalled, however, the company responded by locking out employees. The unresolved issues involved both wages and benefits.

By June 5, all 4,000 employees participated in a strike involving the Rahway plant and six other facilities across the nation. In West Point, Virginia, operations were halted when union picketers prevented nonstriking employees from entering the plant. Merck, however, was able to win a court-ordered injunction limiting picketing.

The strike proved to be the longest in Mercks history; but after 15 weeks an agreement was finally reached. A company request for the adoption of a two-tier wage system that would permanently pay new employees lower wages was rejected, as was a union demand for wage increases and cost-of-living adjustments during the first year. Nevertheless, Mercks reputation as an exceptional, high-paying workplace remained intact, and its subsequent contract agreements were amicable. In fact, Merck was ranked as one of the100 Best Companies to Work for in Americaand one of Working Mother magazines100 Best Companies for Working Motherssince that rankings 1986 inception.

Late 1980s and Early 1990s: Blockbuster Drugs, Joint Ventures, Medco

During the late 1980s, double-digit annual sales increases catapulted Merck to undisputed leadership of the pharmaceutical industry. CEO Vageloss research direction in the 1960s and 1970s laid the foundation for Mercks drugbonanzaof the 1980s. Vasotec, a treatment for congestive heart failure, was introduced in 1985 and became Mercks first billion-dollar-a-year drug by 1988. Mevacor, a cholesterol-lowering drug introduced in 1987, and ivermectin, the worlds top-selling animal health product, also contributed to the companys impressive growth. In the late 1980s, Merck was investing hundreds of millions of dollars in research and developmentten percent of the entire industrys total. Over the course of the decade, Mercks sales more than doubled, its profits tripled, and the company became the worlds top-ranked drug company as well as one of Business Weeks ten most valuable companies.

The company also was recognized for its heritage of social responsibility. In the 1980s, Merck made its drug forriver blindnessa parasitic infection prevalent in tropical areas and affecting 18 million peopleavailable at no charge. In 1987, the company shared its findings regarding the treatment of human immunodeficiency virus (HIV) with competitors. These efforts reflected George W. Mercks assertion:Medicine is for the patients. It is not for the profits. The profits follow, and if we have remembered that, they have never failed to appear. The better we have remembered it, the larger they have been.

Growth did slow in the early 1990s, however, as Mercks drug pipeline dried up. Although the company maintained the broadest product line in the industry, its stable of new drugs was conspicuously absent of theblockbustersthat had characterized the previous decade, with one exception. In 1992 Merck introduced Zocor, a cholesterol-fighting drug that eventually surpassed $1 billion in annual sales and became the companys top-selling drug and one of the most successful pharmaceuticals in history.

In the meantime, Merck entered into a number of joint ventures that created alternative avenues of product development. In 1989 Merck joined with Johnson & Johnson in a venture to develop over-the-counter (OTC) versions of Mercks prescription medications, initially for the U.S. market, later expanded to Europe and Canada. Two years later Merck and E.I. du Pont de Nemours and Company formed a joint venture to research, manufacture, and sell pharmaceutical and imaging agent products. Merck and Connaught Laboratories, Inc. (later part of Aventis S.A.) jointly agreed in 1992 to develop combination vaccines in the United States. In 1994 Merck created a venture with a related company, Pasteur Merieux Connaught (which was also later part of Avetis S.A.), to market combination vaccines in Europe.

In 1993 Merck acquired Medco Containment Services Inc. for $6.6 billion. Medco was a mail-order distributor of drugs that was previously acquired by Martin Wygod in the early 1980s for $36 million. With the help of infamous investment banker Michael Milken, Wygod built Medco into a mass drug distribution system with $2.5 billion in revenues and $138 million in profits by 1992. The acquired company soon was renamed Merck-Medco Managed Care.

The wisdom of the purchase was debated among analysts. On one hand, it was regarded as making Merck more competitive in a U.S. healthcare industry dominated by cost-cutting managed care networks and health maintenance organizations. On the other hand, some observers noted that Mercks newest subsidiary would necessarily distribute competitors drugs and that it had been a major proponent of discounting, which threatened to cut into Mercks R&D funds.

The Medco acquisition also complicated Vageloss plans for a successor. Vageloss choice, Richard J. Markham, resigned unexpectedly in mid-1993, just months before the CEOs anticipated retirement. Some observers speculated that 54-year-old Wygod, with his cost-cutting tendencies and marketing forte, was a likely successor, but he, too, resigned in March 1994. In the end, other internal candidates were bypassed as well in favor of the companys first outsider in Merck history to take the top job, Raymond V. Gilmartin. Named CEO in June 1994 and chairman in November of that year, Gilmartin had helped turn around medical equipment maker Becton Dickinson & Co. as that firms chairman and CEO.

Mid-1990s and Beyond

Although Vagelos had built Merck into its position of industry preeminence by the time of his retirement, the entire pharmaceutical sector was in upheaval stemming from the growth of managed care. Sales and earnings growth were on the decline. Industry pressure resulted in large mergers that created Glaxo Wellcome plc and Novartis AG and toppled Merck from its position as the worlds biggest drugmaker to a tie for third place with Germanys Hoechst Marion Roussel. Merck also was suffering from the difficult 18 months it took to find Vageloss successor and theturf-conscious, defection-riddenculture (so described by Business Weeks Joseph Weber) that Vagelos left behind. One of Gilmartins first major tasks, then, was to restructure the companys management team. In September 1994 he set up a 12-member management committee to help him run the company and plot strategies for growth. The management team included sales executives in Europe and Asia, the heads of the veterinary and vaccine divisions, the president of Merck-Medco, and executives from the research, manufacturing, finance, and legal areas. The creation of this committee helped to streamline and flatten Mercks organizational structure, fostered a greater degree of company teamwork, and halted the exodus of top managers that occurred during the Vagelos succession.

One of the management committees first acts was to create a mission statement for Merck, which affirmed that the company was primarily a research-driven pharmaceutical company. Gilmartin then launched a divestment program, which jettisoned several noncore units, including a generic-drug operation and a managed mental-health care unit. In 1995 Merck sold its Kelco specialty chemicals division to Monsanto Company for $1.1 billion, and its other specialty chemicals unit, Calgon Vestal Laboratories, went to Bristol-Myers Squibb Company for $261 million. These sales also helped Merck pay down the debt it incurred in acquiring Medco, a unit that Gilmartin retained.

There were also two significant divestments in the late 1990s. In July 1997 Merck exited from the agribusiness sector when it sold its crop protection unit to Novartis for $910 million. In July 1998 Merck sold its half-interest in its joint venture with E.I. du Pont to its partner for $2.6 billion. Merck also restructured its animal health unit by combining it with that of Rhone-Poulenc S.A. to form Merial, a stand-alone joint venture created in August 1997. At the end of the 1990s Merial stood as the worlds largest firm focusing on the discovery, manufacture, and marketing of veterinary pharmaceuticals and vaccines. By that time, Mercks partner in Merial was Aventis S.A., which had been formed from the late 1999 merger of Rhone-Poulenc and Hoechst A.G.

Another joint venturethe one formed with Astra in 1982was restructured in the late 1990s. This ventures biggest success came with the December 1996 approval of Prilosec for the treatment of ulcers and heartburn. Prilosec went on to become a blockbuster. In July 1998 Merck and Astra agreed to transform the joint venture into a new limited partnership in which Merck would have no management control but would hold a limited partnership interest and receive royalty payments. This gave Astra more flexibility in terms of seeking a merger partner, and in April 1999 the company merged with Zeneca Group Pic to form AstraZeneca AB. Stemming from this merger and the 1998 agreement between Merck and Astra, Merck received from Astra two one-time payments totaling $1.8 billion.

From 1995 through 1999, Merck introduced a total of 15 new drugs. Gilmartin helped bring these new products to market, but credit for developing them fell to Dr. Edward M. Scolnick, the research chief under Vagelos who stayed with the firm even though he had vied to succeed Vagelos. Within 18 months of Gilmartins arrival, Merck had launched a record eight drugs, including Crixivan, a protease inhibitor used in the treatment of HIV; Fosamax, used to treat osteoporosis; and hypertension medication Cozaar. The eight drugs accounted for more than $1 billion in sales in 1996, about ten percent of the companys total drug sales. Through its joint venture with Johnson & Johnson, Merck also received U.S. approval in April 1995 for the antacid Pepcid AC, an OTC version of Mercks Pepcid.

As the 1990s continued, Merck faced the specter of the expiration of patent protection for some of its biggest-selling productsVasotec and Pepcid were slated to expire in 2000, Mevacor and Prilosec in 2001. These five drugs generated $5.2 billion in U.S. sales in 1997. Under intense pressure to replace thisat least potentiallylost revenue, Merck continued its torrid pace of product debuts. In 1998 the company introduced a record five drugs: Singulair for asthma, Maxalt for migraine headaches, Aggrastat for acute coronary syndrome, Propecia for hair loss, and Cosopt for glaucoma. Merck managed only one drug introduction in 1999, but it was a blockbuster. Making its U.S. debut in May 1999, Vioxx was part of a new category of pain drugs, dubbed Cox-2 inhibitors. Cox-2, an enzyme present in various diseases, was blocked by the new drugs. As a treatment for arthritis, Vioxx was noteworthy for being effective while not irritating the stomach. Despite being second to market behind G.D. Searle & Co.s Celebrex, Vioxx had a remarkable first seven months in which U.S. physicians wrote more than five million prescriptions. The new medication was expected to have sales in 2000 of more than $1 billion, a rapid rise to that level.

Merck headed into the uncertainty of the early 21st century riding a triumphant 1999 wave. In addition to its successful introduction of Vioxx, the company was heartened by the continued strength of its top-selling drug, Zocor, which was gaining market share despite intense competition, particularly from Warner-Lambert Companys Lipitor. Zocor was likely to have worldwide sales of more than $5 billion in 2000. Overall sales in 1999 increased 22 percent, reaching $32.71 billion, while net income increased 12 percent to $5.89 billion. Mercks worldwide pharmaceutical sales totaled $12.55 billion in 1999, placing the company in the number one position. This ranking was unlikely to last, however, thanks to two proposed mergers expected to close in 2000: the U.K. marriage of Glaxo Wellcome pic and SmithKline Beecham plc, and the U.S. coupling of Pfizer Inc. and Warner-Lambert. Mercks Gilmartin stated that he had no interest in such a merger, despite the looming patent expirations. One apparent reason for Gilmartins go-it-alone approach was the companys rapidly growing Merck-Medco unit, which achieved 1999 sales of $15.23 billion. The unit had established the worlds biggest Internet-based pharmacy, merckmedco.com, and formed an alliance with CVS Corporation in 1999 to sell OTC medicines and general health products through this site. Merck-Medco also was helping enhance the sales of Merck drugs, although the FDA launched an investigation in the late 1990s into the practices of pharmacy-benefit management (PBM) firms, including whether any illegalities were taking place in regard to the PBMs steering patients to drugs made by a particular firm. Another reason for optimism about the future of Merck was its continued R&D commitment, represented in 2000 by a $2.4 billion budget. The companys pipeline included a potential blockbuster drug for the treatment of depression and anxiety, which could reach the market by 2001, in addition to several others in various stages of testing.

Principal Subsidiaries

Chibret A/S (Denmark); Hangzhou MSD Pharmaceutical Company Limited (China); International Indemnity Ltd. (Bermuda); Johnson & Johnson-Merck Consumer Pharmaceuticals Company; Laboratorios Prosalud S.A. (Peru); MCM Vaccine Co.; Merck and Company, Incorporated; Merck Capital Investments, Inc.; Merck Capital Resources, Inc.; Merck Enterprises Canada, Ltd.; Merck Foreign Sales Corporation Ltd. (Bermuda); Merck Hamilton, Inc.; Merck Holdings, Inc.; Merck Investment Co., Inc.; Merck Liability Management Company; Merck-Medco Managed Care, L.L.C.; Merck Resource Management, Inc.; Merck Sharp & Dohme (Europe) Inc.; Merck Sharp & Dohme Industria Quimica e Veterinaria Limitada (Brazil); Merck Sharp & Dohme (New Zealand) Limited; Merck Sharp & Dohme Overseas Finance N.V. (Netherland Antilles); Merck Sharp & Dohme (Panama) S.A.; Merck Sharp & Dohme Peru S.C.; Merck Sharp & Dohme (Philippines) Inc.; Merial Limited; MSD International Holdings, Inc.; MSD (Japan) Co., Ltd.; SIBIA Neurosciences, Inc.; The OHare Group, Inc.

Principal Competitors

Abbott Laboratories; American Home Products Corporation; Amgen Inc.; Baxter International Inc.; Bayer AG; Boehringer Ingelheim; Bristol-Myers Squibb Company; Eli Lilly and Company; Express Scripts, Inc.; Glaxo Wellcome pic; Monsanto Company; Novartis AG; Pfizer Inc.; Pharmacia & Upjohn, Inc.; The Procter & Gamble Company; Roche Holding Ltd.; Schering-Plough Corporation; SmithKline Beecham pic; Warner-Lambert Company.

Further Reading

Baldo, Anthony, Merck Plays Hardball, Financial World, June 26,1990, pp. 22 +.

Barrett, Amy, Can Merck Grow Without a Megamerger?, Business Week, June 22, 1998, p. 40.

Byrne, John A., The Miracle Company, Business Week, October 19, 1987, pp. 84 +.

Cloud, David S., Pharmacy-Benefit Management Firms Got Subpoenas in Drug-Marketing Probe, Wall Street Journal, March 7, 2000, p. B7.

Eklund, Christopher S., and Judith H. Dobrynski, Merck: Pouring Money into Basic Research to Replace an Aging Product Line, Business Week, November 26, 1984, pp. 114 +.

Galambos, Louis, and Jane Eliot Sewell, Networks of Innovation: Vaccine Development at Merck, Sharp, & Dohme, and Mulford, 1895-1995, New York: Cambridge University Press, 1995.

Gannes, Stuart, Merck Has Made Biotech Work, Fortune, January 19, 1987, p. 58.

Harris, Gardiner, Cold Turkey: How Merck Intends to Ride Out a Wave of Patent Expirations, Wall Street Journal, February 9, 2000, pp. Al, A8.

Koberstein, Wayne, The Inner Merck: Chairman Ray Gilmartin Charts Pace-Setting Growth, Pharmaceutical Executive, January 2000, pp. 44-48 +.

Langreth, Robert, Merck Raises Its Estimate of Astra Sum, Wall Street Journal, December 10, 1998, p. B7.

Mercky Waters, Economist, May 24, 1997, pp. 59-61.

Nossiter, Daniel D., Blue Chip Bet on Research: Merck to Launch Raft of New Products, Barrons, November 8, 1982, pp. 16 +.

OReilly, Brian, Why Merck Married the Enemy, Fortune, September 20, 1993, pp. 60-64.

Reingold, Jennifer, Mercky Waters, Financial World, January 17,1995, pp. 28-29.

Robertson, Wyndham, Merck Strains to Keep the Pots Aboiling, Fortune, March 1976, p. 134.

Rudnitsky, Howard, Anticipating Hillary, Forbes, August 30, 1993, pp. 44-45.

Scheibla, Shirley Hobbs, Mercks Main Man: He Sees New Drugs Sparking Continued Growth, Barrons, November 11, 1985, pp.13 +.

Seiden, Carl, Why Merck Has to Run Just to Stay in Place, Medical Marketing and Media, August 1998, pp. 38-40, 42, 44, 46.

Smith, Lee, Merck Has an Ache in Japan, Fortune, March 18, 1985, pp. 42 +.

Tanouye, Elyse, Drug Makers PBM Strategy Produces Uneven Results, Wall Street Journal, February 11, 1998, p. B4.

, Gilmartin, Mercks New CEO, Expected to Try Approaches He Used at Becton, Wall Street Journal, June 13, 1994, p. B6.

, Mercks Competition in Key Markets Pressure Earnings, Wall Street Journal, July 24, 1998, p. B4.

Tanouye, Elyse, and Stephen D. Moore, Novartis to Pay $910 Million for Merck Business, Wall Street Journal, May 14, 1997, p. A3.

Warren, Susan, DuPont Is Paying Merck $2.6 Billion to Buy Out 50% Stake in Drug Venture, Wall Street Journal, May 20, 1998, p. A4.

Weber, Joseph, Merck Is Showing Its Age, Business Week, August 23, 1993, pp. 72-74.

, Merck Needs More Gold from the White Coats, Business Week, March 18, 1991, pp. 102 +.

, Merck Wants to Be AloneBut with Lots of Friends, Business Week, October 23, 1989, p. 62. , Mr. Nice Guy with a Mission, Business Week, November 25,1996, pp. 132 +.

, Suddenly, No Heir Is Apparent at Merck, Business Week, July 26, 1993, p. 29.

Weber, Joseph, et al., Merck Finally Gets Its Man, Business Week, June 27, 1994, p. 22.

What the Doctor Ordered, Time, August 18, 1952.

Willatt, Norris, Mercks Unlimited Medicine, Management Today, May 1981, pp. 82 +.

April Dougal Gasbarre

updated by David E. Salamie

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"Merck & Co., Inc.." International Directory of Company Histories. . Encyclopedia.com. 19 Aug. 2017 <http://www.encyclopedia.com>.

"Merck & Co., Inc.." International Directory of Company Histories. . Encyclopedia.com. (August 19, 2017). http://www.encyclopedia.com/books/politics-and-business-magazines/merck-co-inc

"Merck & Co., Inc.." International Directory of Company Histories. . Retrieved August 19, 2017 from Encyclopedia.com: http://www.encyclopedia.com/books/politics-and-business-magazines/merck-co-inc

Merck & Co., Inc.

Merck & Co., Inc.

1 Merck Drive
P.O. Box 1000
White House Station, New Jersey 08889-0100
U.S.A.
(908) 423-1000
Fax: (908) 594-4459

Public Company
Incorporated:
1927
Employees: 47,100
Sales: $10.5 billion
Stock Exchanges: New York Boston Cincinnati Philadelphia Pacific NASDAQ

SICs: 2834 Pharmaceutical Preparations; 2833 Medicinais and Botanicals; 2879 Agricultural Chemicals, Not Elsewhere Classified; 2836 Biological Products Except Diagnostic; 2860 Industrial Organic Chemicals; 2899 Chemicals and Chemical Preparations, Not Elsewhere Classified; 2869 Industrial Organic Chemicals, Not Elsewhere Classified

Merck & Co., Inc. is the largest pharmaceutical company in the world and one of Americas most admired firms. The company also has interests in specialty chemicals. With manufacturing operations in 24 countries, over half of Mercks sales are made outside the United States.

Mercks beginnings can be traced back to Friedrich Jacob Mercks 1668 purchase of an apothecary in Darmstadt, Germany called At the Sign of the Angel. Located next to a castle moat, this store remained in the Merck family for generations.

The pharmacy was transformed by Heinrich Emmanuel Merck into a drug manufactory in 1827. His first products were morphine, codeine, and cocaine. By the time he died in 1855, Merck products were used worldwide. In 1857, Merck sent a representative, Theodore Weicker, to the United States. Weicker (who would go on to own drug powerhouse Bristol-Myers Squibb) was joined by George Merck, the 24-year-old grandson of Heinrich Emmanuel Merck in 1891. In 1899, the younger Merck and Weicker acquired a 150-acre plant site in Rahway, New Jersey, and started production in 1903.

The manufacturing of drugs and chemicals at this site began in 1903. This same location housed the corporate headquarters of Merck and Company and four of its divisions, as well as research laboratories and chemical production facilities, into the 1990s. Once known as Merck Woods, the land surrounding the original plant was used to hunt wild game and corral domestic animals. In fact, George Merck kept a flock of 15 to 20 sheep on the grounds to test the effectiveness of an animal disinfectant. The sheep became a permanent part of the Rahway landscape.

The year 1899 also marked the first year the Merck Manual of Diagnosis and Therapy was published. In 1983, the manual entered its fourteenth edition. A New York Times review rated it the most widely used medical text in the world.

During World War I, George Merck, fearing anti-German sentiment, turned over a sizable portion of Merck stock to the Alien Property Custodian of the United States. This portion represented the company interest held by Mercks German cousins. At the end of the war, Merck was rewarded for his patriotic leadership; the Alien Property Custodian sold Merck shares, worth $3 million, to the public. George Merck retained control of the corporation, and, by 1919 the company was once again entirely public-owned.

By 1926, the year George Merck died, his son George W. Merck had been acting president for over a year. Over the next 25 years, the younger Merck initiated and directed the Merck legacy for pioneering research and development. In 1933, he established a large laboratory and recruited prominent chemists and biologists to produce new pharmaceutical products. Their efforts had far-reaching effects. En route to researching cures for pernicious anemia, Merck scientists discovered vitamin B12. Its sales, both as a therapeutic drug and as a constituent of animal feed were massive.

The 1940s continued to be a decade of discoveries in drug research, especially in the field of steroid chemistry. In the early 1940s, a Merck chemist synthesized cortisone from ox bile, which led to the discovery of cortisones anti-inflammation properties. In 1943, streptomycin, a revolutionary antibiotic used for tuberculosis and other infections, was isolated by a Merck scientist.

Despite the pioneering efforts and research success under George W. Mercks leadership, the company struggled during the postwar years. There were no promising new drugs to speak of, and there was intense competition from foreign companies underselling Merck products, as well as from former domestic consumers beginning to manufacture their own drugs. Merck found itself in a precarious financial position.

A solution was found in 1953 when Merck merged with Sharp & Dohme, Incorporated, a drug company with a similar history and reputation. Sharp and Dohme began as an apothecary shop in 1845 in Baltimore, Maryland. Its success in the research and development of such important products as sulfa drugs, vaccines, and blood plasma products matched the successes of Merck. However, the merger was more than the combination of two industry leaders. It provided Merck with a new distribution network and marketing facilities to secure major customers.

For the first time, Merck could market and sell drugs under its own name.

At the time of George W. Mercks death in 1957, company sales had surpassed $100 million annually. Although Albert W. Merck, a direct descendant of Friedrich Jacob Merck, continued to sit on the board of directors into the 1980s, the office of chief executive was never again held by a Merck family member.

In 1976, John J. Honran succeeded the eleven-year reign of Henry W. Gadsen. Honran wasa quiet, unassuming man who had entered Merck as a legal counselor and then became the corporate director of public relations. But Honrans unobtrusive manner belied an aggressive management style. With pragmatic determination Honran not only continued the Merck tradition for innovation in drug research, but also improved a poor performance record on new product introduction to the market.

This problem was most apparent in the marketing of Aldomet, an antihypertensive agent. Once the research was completed, Merck planned to exploit the discovery by introducing animproved beta-blocker called Blocadren. Yet Merck was beaten to the market by its competitors. Furthermore, because the 17-year patent protection on a new drug discovery was about to expire, Aldomet was threatened by generic manufacturers. This failure to beat its competitors to the market is said to have cost the company $200 million in future sales. A similar sequence of events occurred with Indocin and Clinoril, two anti-inflammation drugs for arthritis.

Under Honrans regime, the company introduced a hepatitis vaccine, a treatment for glaucoma called Timoptic, and Ivomac, an antiparasitic for animals. And while Honran remained strongly committed to financing a highly productive research organization, Merck began making improvements on research already performed by competitors. In 1979, for example, Merck began to market Enalapril, a high-blood pressure inhibitor, similar to the drug Capoten, which was manufactured by Squibb. Sales for Enalapril reached $550 million in 1986. Honran also embarked on a more aggressive program for licensing foreign products. Merck purchased rights to sell products from Astra, a Swedish company, and Shionogi of Japan.

Honrans strategy proved very effective. Between 1981 and 1985, the company experienced a nine percent annual growth rate, and in 1985 the Wall Street Transcript awarded Honran the gold award for excellence in the ethical drug industry. He was commended for the companys advanced marketing techniques and its increased production. At the time of the award, projections indicated a company growth rate for the next five years of double the present rate.

In 1984, Honran claimed Merck had become the largest U.S. based manufacturer of drugs in the three largest marketsthe United States, Japan, and Europe. He attributed this success to three factors: a productive research organization; manufacturing capability which allowed for cost efficient, high-quality production; and an excellent marketing organization. The following year, Honran resigned as chief executive officer. In 1986, his successor, P.R. Vagelos, was also awarded the ethical drug industrys gold award.

Although Mercks public image was generally good, it had its share of controversy. In 1974, a $35 million lawsuit was filed against Merck and 28 other drug manufacturers and distributors of diethylstilbestrol (DES). This drug, prescribed to pregnant women in the late 1940s and up until the early 1960s, ostensibly prevented miscarriages. The 16 original plaintiffs claimed that they developed vaginal cancer and other related difficulties because their mothers had taken the drug. Furthermore, the suit charged that DES was derived from Stilbene, a known carcinogen, and that no reasonable basis existed for claiming the drugs were effective in preventing miscarriages. (A year before the suit, the Federal Drug Administration banned the use of DES hormones as growth stimulants for cattle because tests revealed cancer-causing residues of the substance in some of the animals livers. The FDA, however, did not conduct public hearings on this issue; consequently, a federal court overturned the ban.)

Under the plaintiffs directive, the court asked the defendants to notify other possible victims and to establish early detection and treatment centers. More than 350 plaintiffs subsequently sought damages totalling some $350 billion.

Merck was not only beleaguered by the DES lawsuit. In 1975, the companys name was added to a growing list of U.S. companies involved in illegal payments abroad. The payoffs, issued to increase sales in certain African and Middle Eastern countries, came to the attention of Merck executives through the investigation of the Securities and Exchange Commission. While sales amounted to $40.4 million for that year in those areas of the foreign market, the report uncovered a total of $140,000 in bribes. Once the SEC revealed its report, Merck initiated an internal investigation and took immediate steps to prevent future illegal payments.

More recently, Merck found itself beset with new difficulties. In its attempt to win hegemony in Japan, the second largest pharmaceutical market in the world, Merck purchased more than 50 percent of the Banyu Pharmaceutical Company of Tokyo. Partners since 1954 under a joint business venture called Nippon Merck-Banyu (NMB), the companies used Japanese detail men (or pharmaceutical sales representatives) to promote Merck products.

However, when NMB proved inefficient, Merck bought out its partner for $315.5 millionmore than 30 times Banyus annual earnings. The acquisition was made in 1982, and Merck was still in the process of bringing Banyu into line with its more aggressive and imaginative management style in the early 1990s.

Problems in labor relations surfaced during the spring of 1985 when Merck locked out 730 union employees at the Rahway plant after failing to agree to a new contract. For three months prior to the expiration of three union contracts, involving 4,000 employees, both sides negotiated a new settlement. However, when talks stalled, the company responded by locking out employees. The unresolved issues involved both wages and benefits.

By June 5th, all 4,000 employees participated in a strike involving the Rahway plant and six other facilities across the nation. In West Point, Virginia, operations were halted when union picketers prevented non-striking employees from entering the plant. Merck, however, was able to win a court-ordered injunction limiting picketing.

The strike proved to be the longest in Mercks history; but after 15 weeks an agreement was finally reached. A company request for the adoption of a two-tier wage system which would permanently pay new employees lower wages was rejected, as was a union demand for wage increases and cost-of-living adjustments during the first year. Nevertheless, Mercks reputation as an exceptional, high-paying work place remained intact, and its subsequent contract agreements were amicable. In fact, Merck was ranked as one of the 100 Best Companies to Work for in America and one of Working Mother magazines 100 Best Companies for Working Mothers since that rankings 1986 inception.

During the late 1980s, double-digit annual sales increases catapulted Merck to undisputed leadership of the pharmaceutical industry. CEO Vagelos research direction in the 1960s and 1970s laid the foundation for Mercks drug bonanza of the 1980s. Vasotec, a treatment for congestive heart failure, was introduced in 1985 and became Mercks first billion-dollar-a-year drug by 1988. Mevacor, a cholesterol-lowering drug, and ivermectin, the worlds top-selling animal health product, also contributed to the companys impressive growth. In the late 1980s, Merck was investing hundreds of millions of dollars in research and developmentten percent of the entire industrys total. Over the course of the decade, Mercks sales more than doubled, its profits tripled, and the company became the worlds top ranked drug company as well as one of Business Weeks ten most valuable companies.

The company was also recognized for its heritage of social responsibility. In the 1980s, Merck made its drug for river blindnessa parasitic infection prevalent in tropical areas and affecting 18 million peopleavailable at no charge. In 1987, the company shared its findings regarding the treatment of human immunodeficiency virus (HIV) with competitors. These efforts reflected George W. Mercks assertion that: Medicine is for the patients. It is not for the profits. The profits follow, and if we have remembered that, they have never failed to appear. The better we have remembered it, the larger they have been.

Growth did slow in the early 1990s, however, as Mercks drug pipeline dried up. Although the company maintained the broadest product line in the industry, its stable of new drugs was conspicuously absent of the blockbusters that had characterized the previous decade.

In July 1993, Vagelos announced Mercks intention to acquire Medco Containment Services Inc. for $3.6 billion in cash, $2.4 billion in borrowings, and 112 new shares of stock. Medco was a mail-order distributor of drugs that was previously acquired by Martin Wygod in the early 1980s for $36 million. With the help of infamous investment banker Michael Milken, Wygod built Medco into a mass drug distribution system with $2.5 billion in revenues and $138 million in profits by 1992.

The wisdom of the purchase was debated among analysts. On one hand, it was regarded as making Merck more competitive in an American health care industry dominated by cost-cutting managed care networks and health maintenance organizations. On the other hand, some observers noted that Mercks newest subsidiary would necessarily distribute competitors drugs and that it had been a major proponent of discounting, which threatened to cut into Mercks R&D funds.

The Medco acquisition also complicated Vagelos plans for a successor. Vagelos choice, Richard J. Markham, resigned unexpectedly in mid-1994, just months before the CEOs anticipated retirement. Some observers speculated that 54-year-old Wygod, with his cost-cutting tendencies and marketing forte, was a likely successor in the health-care industry of the 1990s.

Principal Subsidiaries

Chibret A/S; International Indemnity Limited (Bermuda); Kelco Specialty Colloids, Limited (Canada); Laboratories Prosalud S.A. (Peru); Medco Containment Services, Inc.; Merck and Company, Incorporated; Merck Capital Resources, Inc.; Merck Foreign Sales Corporation (Guam); Merck Foreign Sales Corporation Ltd.(Bermuda); Merck Holdings, Inc.; Merck Investment Co., Inc.; Merck Sharp & Dohme Inc. (Europe); Merck Sharp & Dhome Industria Quimica e Veterinaria Limitada (Brazil); Merck Sharp & Dohme, Limitada (Portugal); Merck Sharp & Dohme Limited (New Zealand); Merck Sharp & Dohme Overseas Finance N.V. (Netherland Antilles); Merck Sharp & Dohme S.A. (Panama); Merck Sharp & Dohme Scientific and Management Corp., Inc.; Merck Sharp & Dohme Limited (Zimbabe) (Private); MSD AGVET AG (Switzerland); MSD Co. (Japan).

Further Reading

OReilly, Brian, Why Merck Married the Enemy, Fortune, September 20, 1993, pp. 60-64.

Rudnitsky, Howard, Anticipating Hillary, Forbes, August 30, 1993, pp. 44-45.

Weber, Joseph, Merck is Showing its Age, Business Week, August 23, 1993, pp. 72-74.

Weber, Joseph, Suddenly, No Heir is Apparent at Merck, Business Week, July 26, 1993, p. 29.

updated by April Dougal Gasbarre

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"Merck & Co., Inc.." International Directory of Company Histories. . Encyclopedia.com. 19 Aug. 2017 <http://www.encyclopedia.com>.

"Merck & Co., Inc.." International Directory of Company Histories. . Encyclopedia.com. (August 19, 2017). http://www.encyclopedia.com/books/politics-and-business-magazines/merck-co-inc-0

"Merck & Co., Inc.." International Directory of Company Histories. . Retrieved August 19, 2017 from Encyclopedia.com: http://www.encyclopedia.com/books/politics-and-business-magazines/merck-co-inc-0