James Dewey Watson was the codiscoverer of the structure of DNA. He has also made major contributions to research in genetics and molecular biology as an administrator, and has written widely read and influential books for both academic and nonscience audiences.
Early Life and Training
Watson was born April 6, 1928, in Chicago, Illinois. He showed his brilliance early, finishing high school in two years and appearing as one of the original "Quiz Kids," on a popular 1940s radio show of the same name. He was graduated from the University of Chicago in 1947 with a B.S. in zoology, reflecting an early love of birds. He did his doctoral work at Indiana University in genetics, and earned a Ph.D. in 1950. He was drawn to Indiana by the chance to work with Hermann Joseph Muller, who had been one of Thomas Hunt Morgan's associates in the famous "fly room" at Columbia University, and who had received a Nobel Prize for his discoveries in genetics. Watson's thesis adviser and principal mentor was Salvador Luria, who, along with Max Delbrück, had established bacterial genetics as the experimental system in which most of the major discoveries in molecular biology were to be made. Watson's thesis was on the effect of X rays on the multiplication of a bacterial virus, called phage.
Watson continued to study phage as a postdoctoral student in Copenhagen, Denmark where he worked from 1950 to 1951. While there, he met Maurice Wilkins, and for the first time saw the X-ray diffraction images generated in Wilkins's lab by Rosalind Franklin. Watson quickly decided to turn his attention to discovering the structure of important biological molecules, including DNA and proteins. By that time, DNA had been shown to be the genetic molecule, and it was believed that it somehow carried the instructions for making proteins, which actually perform most of the work in a cell.
The Structure of DNA
Luria arranged for Watson to continue his work at the Cavendish Laboratory in Cambridge, England, which was a center for the study of biomolecular structure, and Watson arrived there in late 1951. At the Cavendish, he met Francis Crick, who, after training in physics, had turned his attention to similar structural questions. The two hit it off, and began collaborating on the structure of DNA.
Watson and Crick approached the problem by building models of the four nucleotides known to make up DNA. Each was composed of a sugar called deoxyribose, a phosphate group, and one of four bases, called ade-nine, thymine, cytosine, and guanine. They knew the sugars and phosphates alternated to form a chain, with the bases projecting off to the side. The X-ray images they had seen suggested the structure was a helix, and offered more information about dimensions as well. They also knew that the biochemist Erwin Chargaff had discovered that the amounts of adenine and thymine in a cell's DNA were equal, as were the amounts of cytosine and guanine.
After several failed attempts, more analysis of the X-ray images, and a fortuitous conversation with a biochemist who corrected one of their hypothesized base structures, they developed the correct model. The helix is formed from two opposing strands of sugar phosphates, while the bases project into the center. Weak bonding (called hydrogen bonding ) between bases holds them together. The key, as Watson and Crick discovered, was that the hydrogen bonds work best when adenine pairs with thymine, and guanine with cytosine, thus explaining Chargaff's ratios. The structure immediately suggested a replication mechanism, in which each side serves as the template for the formation of a new copy of the opposing side, and they speculated, correctly, that the sequence of the bases was a code for the sequence of amino acids in proteins. They published their results in 1953, and received the Nobel Prize for physiology and medicine for it 1962, along with Wilkins (Franklin by then had died, and was therefore ineligible for the prize).
Watson remained active in the study of DNA and RNA for a number of years after the publication of the DNA structure. He joined the faculty of Harvard University in 1955, and remained there until 1976. During this time, he wrote an influential textbook, Molecular Biology of the Gene, and an enormously popular (and colorful) account of his and Crick's discovery, called The Double Helix.
In 1968 Watson became the director of the Cold Spring Harbor Laboratory on Long Island, New York, and he became president of the laboratory in 1994, a position he continues to hold. Watson revitalized this laboratory, helping it become one of the premier genetics research institutions in the world. His organizational drive was also called upon in 1988, when he spearheaded the launch of the U.S. Human Genome Project, dedicated to determining the sequence of the entire three billion bases in the genome. He headed the project from 1988 to 1992.
Throughout his career, Watson has invariably been described as "brash," reflecting his capacity to take on big projects and big ideas, and his enthusiasm for making daring, occasionally outrageous predictions about the causes of an unexplained phenomenon or the direction science will take. Explaining this tendency in relation to his work on DNA, Watson wrote, "A potential key to the secret of life was impossible to push out of my mind. It was certainly better to imagine myself becoming famous than maturing into a stifled academic who had never risked a thought."
see also Crick, Francis; Delbrück, Max; DNA; DNA Structure and Function, History; Morgan, Thomas Hunt; Muller, Hermann; Nucleotide.
Judson, Horace F. The Eight Days of Creation, expanded edition. Cold Spring Harbor, NY: Cold Spring Harbor Press, 1996.
Watson, James. The Double Helix: A Personal Account of the Discovery of the Structure of DNA. New York: New American Library, 1991.
———. Genes, Girls, and Gamow: After the Double Helix. New York: Knopf, 2002.
"Biographical Sketch of James Dewey Watson." <http://nucleus.cshl.org/CSHLlib/archives/jdwbio.htm>.
"Watson, James." Genetics. . Encyclopedia.com. (May 22, 2017). http://www.encyclopedia.com/medicine/medical-magazines/watson-james
"Watson, James." Genetics. . Retrieved May 22, 2017 from Encyclopedia.com: http://www.encyclopedia.com/medicine/medical-magazines/watson-james
James Dewey Watson, American biologist, won the Nobel Prize in 1962 for the discoveries he made in molecular genetics, along with Francis Crick and Maurice Wilkins.
Watson began his university studies at the age of fifteen at the University of Chicago, from which he graduated at nineteen. While in college, Watson was deeply affected by the writings of Erwin Schrodinger, who was among the first to articulate the concept of the gene. Watson received his doctoral degree in 1950 from Indiana University, after conducting research on bacterial viruses.
After receiving his Ph.D., Watson won a fellowship from the Merck Foundation and spent a year furthering his study of bacterial viruses in Copenhagen, Denmark. From Copenhagen, Watson moved on to Cambridge University, where he first met and collaborated with Frances Crick, a young British biophysicist.
In 1952, Watson and Crick began to investigate the molecular structure, and significance to genetics, of nucleic acids. The collaborators began by looking specifically at the earlier work done by Maurice Wilkins and Rosalind Franklin on X-ray crystallography analysis of deoxyribonucleic acid (DNA), a substance that was already considered to make genes, the fundamental units of heredity.
Watson and Crick used Wilkins's and Franklin's data to create a three-dimensional model of the DNA molecule. Watson and Crick hoped that their model would agree with the chemical facts previously established about DNA; for example, that DNA consisted of phosphates, nitrogenous bases, and sugars. In addition, Wilkins's X-ray crystallography experiments had already determined many of the patterns by means of which such molecules were connected.
Watson and Crick tried out various ways of arranging model molecules in space, finally settling on the aptly named "double helix." Their model, afterward referred to as the Watson-Crick model, showed DNA as a twostranded twisted "helix." The two strands consisted of complementary pairs of nucleotide units. This model both matched chemical facts previously known about DNA, and provided a viable explanation for how DNA could replicate, and thus for how genetic information could pass from one generation to the next generation of living organisms.
Between 1956 and 1976, Watson ran a laboratory at Harvard University, where he also taught courses in biology. Additionally, in 1969 he was named director of the Cold Spring Harbor Laboratory in New York State. In 1991, Watson became the first director of the Human Genome Project, established by a consortium of public agencies to sequence the entire human genome, but he later resigned over the issue of patenting human genes. Among his notable publications are Molecular Biology of the Gene (1965) and The Double Helix (1968).
see also Crick, Francis
Hanna Rose Shell
Crick, Francis. What Mad Pursuit? New York: Basic Books, 1988.
Sherborn, Victoria. James Watson and Francis Crick: Decoding the Secrets of DNA. Woodbridge, CT: Blackbirch Press, 1995.
Strathern, Paul. The Big Idea: Crick, Watson and DNA. New York: Anchor, 1997.
Watson, James. The Double Helix. New York: Norton Press, 1968.
"Watson, James." Biology. . Encyclopedia.com. (May 22, 2017). http://www.encyclopedia.com/science/news-wires-white-papers-and-books/watson-james
"Watson, James." Biology. . Retrieved May 22, 2017 from Encyclopedia.com: http://www.encyclopedia.com/science/news-wires-white-papers-and-books/watson-james