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lock-and-key theory

A Dictionary of Zoology | 1999 | Copyright

lock-and-key theory A theory to explain the mechanism of enzymatic reactions, in which it is proposed that the enzyme and substrate(s) bind temporarily to form an enzyme–substrate complex. The binding site on the enzyme is known as the ‘active site’ and is structurally complementary to the substrate(s). Thus the enzyme and substrate(s) are said to fit together as do a lock and a key.

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MICHAEL ALLABY. "lock-and-key theory." A Dictionary of Zoology. 1999. Encyclopedia.com. 9 Feb. 2010 <http://www.encyclopedia.com>.

MICHAEL ALLABY. "lock-and-key theory." A Dictionary of Zoology. 1999. Encyclopedia.com. (February 9, 2010). http://www.encyclopedia.com/doc/1O8-lockandkeytheory.html

MICHAEL ALLABY. "lock-and-key theory." A Dictionary of Zoology. 1999. Retrieved February 09, 2010 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O8-lockandkeytheory.html

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Related entries from encyclopedias, dictionaries, and thesauruses

	lock-and-key theory Book article from: A Dictionary of Plant Sciences lock-and-key theory A theory to explain the mechanism of enzymatic reactions, in which it is proposed that the enzyme and...the substrate(s). Thus, the enzyme and substrate(s) are said to fit together as do a lock and a key.
	lock-and-key mechanism Book article from: A Dictionary of Biology ...to have a fixed structure (the lock), which exactly matched the structure of a specific substrate (the key). Thus the enzyme and substrate...enzyme is more flexible than the lock-and-key theory would suggest. Compare induced...
	induced-fit theory Book article from: A Dictionary of Zoology induced-fit theory A variation of the lock-and-key theory of enzymatic function. It is proposed that the substrate causes a conformational change in the enzyme such that the active site achieves the exact configuration required for a reaction...
	induced fit theory Book article from: A Dictionary of Plant Sciences induced fit theory A variation of the lock-and-key theory of enzymatic function. It is proposed that the substrate causes a conformational change in the enzyme such that the active site achieves the exact configuration required for a reaction...
	constitutive enzyme Book article from: A Dictionary of Zoology ...whether or not a suitable substrate is present (enzymes functioning by forming a complex with the substrate, see LOCK-AND-KEY THEORY ). Such enzymes are sometimes produced by particular regulatory mutants which, though not affecting the structure...