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gene therapy
gene therapy
gene therapy The application of genetic engineering techniques to alter or replace defective genes. A defective gene may result from an incorrect sequence of bases in the DNA molecule or an inability of the gene to code for the expression of a particular polypeptide. Techniques currently being investigated involve the transfer of normal genes into the genetic material of the cell to replace the defective gene and the use of
antisense RNA to ‘knock out’ defective genes in certain tissues.
Retroviruses are often used as
vectors for transferring genes into cells as part of the natural retrovirus life cycle involves the insertion of their own genetic material into the chromosomes of their host. Alternatively
liposomes may be used. Gene therapy is being developed in an attempt to cure and prevent such genetic diseases as cystic fibrosis.
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Hyping gene therapy: it's no magic bullet for curing dread diseases.
Magazine article from: U.S. News & World Report; 11/14/1994; ; 700+ words
; ...symbol of the promise of gene therapy, the high-tech medical...have relentlessly touted gene therapy's wonders. Recently, scientific...announced advances in gene therapies for cancer, heart disease...backers concede that gene therapy will not be arriving at your...it ...
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Gene therapy benefit said to outweigh risk.
News Wire article from: United Press International; 10/10/2002; 700+ words
; ...begin the first ever gene therapy trial for treating...noted different gene therapies use different vectors...director of gene therapy laboratories at the...taking a closer look at gene therapy trials and instituting...are so alert to gene therapy that ...
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Gene Therapy Advisory Committee Annual Report published; UK leads Europe in this field - Health Minister Lord Hunt.
M2 Presswire; 1/31/2003; 700+ words
; ...acceptability of proposals for gene therapy research on humans...Ministers on developments in gene therapy research. In the UK...to benefit from gene therapies (melanoma, brain tumours...ethical aspects of gene therapy clinical trials. It...
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Gene Therapy: Ushering in a New Era in Disease Treatment.
PR Newswire; 11/22/2005; 700+ words
; ...PRNewswire/ -- Gene therapy is generating great...diseases by inserting genes into the target cells...com/ ), U.S. Gene Therapies Market, reveals that...of the U.S. Gene Therapies Market, then send...information. "Gene therapy research has made ...
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GENE THERAPY BENEFIT SAID TO OUTWEIGH RISK
News Wire article from: United Press International; 10/10/2002; 700+ words
; ...begin the first ever gene therapy trial for treating...noted different gene therapies use different vectors...director of gene therapy laboratories at the...taking a closer look at gene therapy trials and instituting...are so alert to gene therapy that ...
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Gene therapy for oral squamous cell carcinoma: An overview.(Review Article)
Magazine article from: Indian Journal of Dental Research; 7/1/2007; ; 700+ words
; ...March 2004, 619 gene therapy / transfer clinical protocols...regulators-tumour suppressor genes.[sup] [9],[10...p53 tumour suppressor gene result either in the...oncogenes and mutations in genes coding for cell adhesion...sup] [12] Concept of Gene Therapy Gene ...
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When Gene Therapy Makes Cells Hit The SCIDs.
Magazine article from: BIOWORLD Today; 8/11/2006; ; 700+ words
; ...immunodeficient animals with gene therapy carries special risks compared...that are good candidates for gene therapy treatment. The researchers...leukemia to occur after gamma chain gene therapy, mice needed to lack...suppressor and the gamma chain genes - in other words, ...
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Immunological Gene Therapy And Tumor Debulking Delays Mesothelioma Growth.
Newspaper article from: Gene Therapy Weekly; 10/11/2001; 700+ words
; ...augmentative therapies combining immunological gene therapy with tumor debulking...transfer of genes encoding for...immunological gene therapy is somewhat...surgery nor gene therapy alone delayed...the two gene therapies were combined...design of human ...
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SAFETY OF GENE THERAPY:JAY P. SIEGEL
Transcript from: Congressional Testimony; 2/2/2000; 700+ words
; ...Cosmetic (FD&C) Act.' Gene therapy products present extraordinarily...and human viruses to produce gene vectors (carriers of genes), to the ethical and social...involved with the potential for gene alteration in utero and other...
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Gene therapy in medicine.
Magazine article from: Indian Journal of Ophthalmology; 10/1/2002; ; 700+ words
; ...episome-mediated gene therapy is preferred. For example, cancer gene therapies often involve transfer and expression of genes into cancer cells...the therapeutic gene may no longer be...delivery Most gene therapy protocols have used...
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Gene Therapy
Encyclopedia entry from: The Gale Encyclopedia of Science
Gene Therapy Gene therapy refers to the deliberate introduction of genes into an organism. The intent...lifestyle). The objective of gene therapy is to treat diseases by introducing corrected genes into the body to replace...
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Gene Therapy: Ethical Issues
Book article from: Genetics
...ethical implications. Gene therapy using germ line cells...fertilization, the gene transfer could also...appeal of germ line gene therapy is its potential for...Successful germ line therapies introduce the possibility...people view this type of therapy as unnatural, and ...
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Viral Vectors in Gene Therapy
Book article from: World of Microbiology and Immunology
Viral vectors in gene therapy Gene therapy is the introduction of a gene into cells to reverse a functional defect caused by a defect in a host genome (the set of genes present in an organism). The use of viruses quickly...
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gene therapy
Book article from: The Columbia Encyclopedia, Sixth Edition
gene therapy the use of genes and the techniques of genetic...are many techniques of gene therapy, all of them still...called in vivo and ex vivo gene therapy. The in vivo method...inserts genetically altered genes directly into the patient...
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gene replacement therapy
Book article from: World Encyclopedia
gene replacement therapy ( GRT ) Medical treatment...replacement or alteration of faulty genes by means of genetic engineering...experimental procedure. A healthy gene is packaged into some kind...affected cells. Initially, gene therapy was restricted to...
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